Why do we not talk about entropy when deciding feasibility of an organic reaction?...We always seem to only be interested in stability of product and intermediate(essentially delta H)and draw their respective graphs of Delta H of the reaction showing the peak of intermediate..shouldn't we look at change in Gibbs free energy for commenting on feasibility?

  • $\begingroup$ What do you mean when you say "feasibility?" $\endgroup$
    – Zhe
    Jul 7 '19 at 19:00
  • $\begingroup$ Spontaneity .. regarding whether the reaction proceeds through a certain pathway here $\endgroup$ Jul 7 '19 at 19:01
  • 1
    $\begingroup$ You'd have to show an example of what you're talking about, but in my experience, reaction coordinate diagrams always have free energy on the vertical axis. We do provide bond dissociate enthalpies in tables, but that's because the entropic component is not easy to generalize. $\endgroup$
    – Zhe
    Jul 7 '19 at 19:05
  • $\begingroup$ I mean we only talk about relative stabilities (and not entropy )of various intermediates while deciding which pathway the reaction will follow..why is that? $\endgroup$ Jul 7 '19 at 19:15
  • 1
    $\begingroup$ That depends on what you mean by stabilities. If you're talking about stability as measured via a free energy, that is the most accurate way to do it, since free energy is a proxy for the total entropy change of the universe, which is the specific quantity that has restrictions based on the second law of thermodynamics. $\endgroup$
    – Zhe
    Jul 7 '19 at 19:16

Your Answer

By clicking “Post Your Answer”, you agree to our terms of service, privacy policy and cookie policy

Browse other questions tagged or ask your own question.