I know $\mathrm{S_N2}$ is favored polar aprotic solvents, which means that they may have hydrogens on them somewhere, but they lack $\ce{O-H}$ or $\ce{N-H}$ bonds, and therefore cannot hydrogen bond with themselves.

But I found that $\mathrm{S_N2/E2}$ is favored by $\ce{OH-, RO-}$ (a strong base); if I look at $\ce{OH-}$, doesn't it contain $\ce{O-H}$ and form hydrogen bonds?

Can someone please explain what aprotic solvents then? Are aprotic solvents a strong base? What's the difference between aprotic solvents and a strong base?


  • 2
    $\begingroup$ OH- in what solvent? Powdered KOH in THF reacts in a very different way from KOH in MeOH. $\endgroup$ – Waylander Jun 16 at 16:52
  • $\begingroup$ This was not mentioned . $\endgroup$ – Who Jun 16 at 16:56

Your Answer

By clicking “Post Your Answer”, you agree to our terms of service, privacy policy and cookie policy

Browse other questions tagged or ask your own question.