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I have a project that would require cannabigerolic acid (CBGA) as a synthase substrate, but the only available chemical I can find is cannabigerol (CBG). CBG is the product of CBGA through decarboxylation at about 105 °C. Is this reaction reversible? How can I carboxylate the CBG I have available into CBGA?

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  • $\begingroup$ Looks like you need to exploit the reactivity of the bis-hydroxylated aromatic ring. Reimer-Tiemann variation with CCl4 perhaps? But not sure, the molecule looks a bit delicate. $\endgroup$
    – user6376297
    Commented Jun 16, 2019 at 8:08

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The substrate is a resorcinol derivative: a strongly activated aromatic ring, which upon reaction with a base delocalizes its negative charge on the ring, making it reactive towards acids (Eg. CO2).

Here (entries 130-132) good conversion is claimed (85%) in a high pressure vessel with magnesium methoxide and dry ice, or a lower conversion (40%) is reported at ambient pressure with magnesium methyl carbonate

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