I have a project that would require cannabigerolic acid (CBGA) as a synthase substrate, but the only available chemical I can find is cannabigerol (CBG). CBG is the product of CBGA through decarboxylation at about 105 °C. Is this reaction reversible? How can I carboxylate the CBG I have available into CBGA?
The substrate is a resorcinol derivative: a strongly activated aromatic ring, which upon reaction with a base delocalizes its negative charge on the ring, making it reactive towards acids (Eg. CO2).
Here (entries 130-132) good conversion is claimed (85%) in a high pressure vessel with magnesium methoxide and dry ice, or a lower conversion (40%) is reported at ambient pressure with magnesium methyl carbonate