I have a project that would require cannabigerolic acid (CBGA) as a synthase substrate, but the only available chemical I can find is cannabigerol (CBG). CBG is the product of CBGA through decarboxylation at about 105 °C. Is this reaction reversible? How can I carboxylate the CBG I have available into CBGA?

  • $\begingroup$ Looks like you need to exploit the reactivity of the bis-hydroxylated aromatic ring. Reimer-Tiemann variation with CCl4 perhaps? But not sure, the molecule looks a bit delicate. $\endgroup$ Jun 16, 2019 at 8:08

1 Answer 1


The substrate is a resorcinol derivative: a strongly activated aromatic ring, which upon reaction with a base delocalizes its negative charge on the ring, making it reactive towards acids (Eg. CO2).

Here (entries 130-132) good conversion is claimed (85%) in a high pressure vessel with magnesium methoxide and dry ice, or a lower conversion (40%) is reported at ambient pressure with magnesium methyl carbonate


Your Answer

By clicking “Post Your Answer”, you agree to our terms of service and acknowledge you have read our privacy policy.

Not the answer you're looking for? Browse other questions tagged or ask your own question.