My son has autism and we noticed that blueberries make him feel much better. The problem is blueberries contain sugars which interfere with diet he has (low carbohydrate).

How do I filter out the sugars (fructose?) without interfering with other compounds present in the juice? We can't add yeast and wait. Perfect option would be to add something that interacts only with the sugars and produces something neutral to the human body or is easily removed.

  • $\begingroup$ You could culture the juice under aerobic conditions. Tart blueberry juice actually sounds delicious (to me anyway). $\endgroup$
    – user79498
    May 23, 2019 at 17:55
  • $\begingroup$ You could try unripe blueberries. $\endgroup$
    – Carl Emil
    Jun 15, 2021 at 10:04
  • 1
    $\begingroup$ What in the blueberries makes him feel much better? I wonder (as a contrarian) if the low carbohydrate diet makes him feel worse, so the sugars make him feel better. A test would be to give him some honey (~40% glucose, 40% fructose) diluted in water (maybe add some blue food color?) to see if that makes him feel better. Fructose is sweet; blue is pretty; glucose is a brain food... $\endgroup$ Jun 15, 2021 at 15:04

1 Answer 1


A blueberry contains ~85% water, 5% glucose, and 5% fructose (and it is generally considered a low glycemic index food, see e.g. this site). The solubility of fructose in water is extremely high (wikipedia says ~4000 g/L (25 °C), pubchem says "freely soluble in water"), and that of glucose is pretty high too, so there is essentially zero chance of removing these sugars through crystallization or other method without significantly altering the fruit or its juice.

If you are still interested in generating an extract of the fruit, this article might be useful. It suggests two different approaches, juicing and drying. The first will generate juice and a press cake, and since the sugars are highly water-soluble the cake should be the reduced-sugar component of interest to you. You could also freeze dry the juice, assuming this contains the important components, then partially rehydrate the dry product and attempt to crystalize out sugars. Or you could dry the whole fruit and then attempt a separation with ethanol, with sugar extracted into the alcohol to obtain a reduced-sugar extract which can then be dried. Further separations with more apolar solvents might extract hydrophobic "phytonutrients" from the juice. But you are likely to remain somewhat in the dark with respect to what you've removed from the berry without further analytical tools to help you characterize the products.

There are alternatives to extraction of the sugar that involve biochemical conversion of the monosaccharides. One alternative is to treat crushed blueberry with xylose isomerase, which would convert the glucose to fructose. Fructose has a low GI ranking, which might be a benefit. Another alternative is to treat the blueberry with a mixture of enzymes (perhaps including sucrose-sucrose 1-fructosyltransferase (1-SST), see e.g. this example) that converts the glucose/fructose mixture into largely indigestible polysaccharides (soluble dietary fiber).

Otherwise the best solution might remain to eat the fruit raw or to seek other foods with similar composition and without sugar (perhaps you should consult a dietitian).

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    $\begingroup$ Offering the blueberries in moderation while reducing carbohydrates in the remainder of the diet seems a good approach. $\endgroup$ May 22, 2019 at 19:46
  • $\begingroup$ Is there a compound that reacts only with glucose/fructose producing something that's easier to separate? $\endgroup$
    – blueb
    May 28, 2019 at 12:38
  • $\begingroup$ @blueb I don't know off the bat of one but there would surely be some way, although perhaps not currently practical. Also, I added a similar idea to the answer. $\endgroup$
    – Buck Thorn
    May 28, 2019 at 15:37

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