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I am trying to synthesize poly(ethylene-propylene)amine, i.e.:

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I've read that Reductive Amination is efficient regarding the reaction yield. However, it needs aldehydes to start the reaction. To make the aldehydes I can use this way and start from the hydroxyl-terminated polymer compound. I reach to a dilemma here where my experience is not enough to decide which way to go. I can start with a aldehyde-terminated polymer at first so I don't have to make it from an OH-terminated polymer.

Which way do you suggest? A reference on how to do the one you recommend is also appreciated.

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Before I offer an answer understand that I am a general synthetic chemist used to working in solution phase, and I have not worked with polymers. Absent an answer from someone who has here is how I would tackle this using OH-terminated polymer.

1 -reaction with methanesulfonyl chloride/triethylamine to activate the -OH for displacement. This is known as mesylation more here and here

2- reaction with sodium azide in DMF or DMSO to give the alkyl azide

3- reduction of the alkyl azide to the amine with triphenyl phosphine Staudinger reduction

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