How is the primary kinetic isotope effect (KIE) observed in the E1cB reaction when breaking of the $\ce{C}$-$\ce{H}$ bond is not the rate determining step of this reaction?

  • $\begingroup$ There is a section on Wikipedia describing KIEs in the E1cb reaction in quite some detail: en.wikipedia.org/wiki/… Have you already seen that? Is there something specific you don't understand about it? $\endgroup$ – orthocresol Apr 14 '19 at 9:22
  • $\begingroup$ Is it like....1) A Deuterium 'Exchange' indicates that an E1CB REVERSIBLE reaction has taken place, & ...2) A beta deuterium substituted reactant showing primary kinetic isotopic effect indicates that an E1CB IRREVERSIBLE reaction has taken place? I'm confused. Please help. $\endgroup$ – Anonymous Apr 14 '19 at 11:15

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