I'm trying to prepare protected urea and I'd like to protect it with some alkali stable PG. Is it possible to protect urea with t-Boc? Or is there another way to get boc-protected urea? enter image description here

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    $\begingroup$ Its commercially available. Google "boc urea". $\endgroup$ – user55119 Mar 20 '19 at 22:11
  • $\begingroup$ Thank you for the answer, but I'd like to prepare my own. We are not allowed to order from China (University rules) and I have all starting materials that I possibly need. $\endgroup$ – Petr Slávik Mar 20 '19 at 22:43
  • $\begingroup$ Reflux with BOC2O and DMAP in MeCN $\endgroup$ – Waylander Mar 20 '19 at 22:45
  • $\begingroup$ Check this:Tetrahedron Lett. 2014, 55(4), 842–844 (but method is for mono-protected). $\endgroup$ – Mathew Mahindaratne Mar 20 '19 at 22:46
  • $\begingroup$ Thank you both for answers Waylander and Mathew, I will try to run this reaction tomorrow. $\endgroup$ – Petr Slávik Mar 20 '19 at 22:57

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