I need to make a citrate-sodium citrate buffer at 0.5 M concentration and pH 4.5. I calculated the molarities of the citrate and disodium citrate based on the Henderson Hasselbalch equation, using a pKa of 4.76 . To cross-check my calculations, I tried a couple of online calculators, but the results are way off from mine. I think the formulae should change based on where I use monosodium, disodium or trisodum citrate. What is the right way to go about making this calculation?

  • $\begingroup$ The relevant pKa for the trisodium citrate/disodium hydrogen citrate pair is 6.40. $\endgroup$ – Karsten Theis Jan 15 at 14:54

Your Answer

By clicking "Post Your Answer", you acknowledge that you have read our updated terms of service, privacy policy and cookie policy, and that your continued use of the website is subject to these policies.

Browse other questions tagged or ask your own question.