Title says it all. Wondering if imine formation would work with an aldehyde, even better would be formaldehyde.


Yes it does. They are reactive species, methylene imines particularly are easily hydrolysed back to amine + aldehyde.

They are the basis of reductive methylation/alkylation of primary amines where reaction with alkyl halides, especially reactive ones such as MeI risks dialkylation. More details here reductive alkylation

  • $\begingroup$ Thank you, I figured it would but couldn't wanted to make sure before I used it in a presentation. Also, I was wondering about alkylation of ammines for a while now! $\endgroup$ – Ronnie Nov 17 '18 at 5:14
  • $\begingroup$ @ronnie Please accept the answer if you are happy with it $\endgroup$ – Waylander Nov 17 '18 at 8:06

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