# Do bulky bases participate in substitution reactions?

I see how bulky bases influence the regioselectivity of E2 and E1 reactions. I do not see very much content on the involvement of bulky bases in substitution reactions.

I know that bulky bases like t-BuOK are generally not involved in substitution reactions because the t-BuO ion would prefer to take a β-hydrogen instead. Are any substitution reactions possible, and if so, what mechanism would be seen in substitution reactions involving bulky bases?

• The clue is in your title - "bulky bases" . Steric hindrance is a very real effect Nov 3 '18 at 17:03