I am a molecular biologist and work with recombinant proteins. I am wondering what the cut point, in terms of length, is at which I should produce the peptide using heterologous expression rather than ordering a peptide synthesis service? What is the maximum length which makes it hard to chemically synthesis the peptide? Any ideas are welcome.
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The protein lysozyme (160 amino acids) has been synthesized using a flow reactor according to https://www.chemistryworld.com/news/protein-synthesis-revolution-on-way-as-large-peptides-made-in-hours-not-days/4011891.article . The same article suggest 50 amino acids as a cut-off where the traditional solid state synthesis would be infeasible.
