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bon
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An $E2$$\mathrm{E2}$ (or $E1cb$$\mathrm{E1cb}$) mechanism requires antiperiplanar configuration. In case of restricted rotations, like in cycles, where rotation is not possible to achieve the antiperiplanar configuration, elimination occurs to favour the Hofmann product instead of the Zaitsev, if antiperiplanar configuration is possible at the less substituted β C. In menthyl chloride,

enter image description here

In menthyl chloride, antiperiplanar configuration is only seen with the red $\ce{H}$, so 2 menthene is the only product, although it is not the most substituted. In

enter image description here

againIn the molecule above, due to restricted rotation, the leaving group $\ce{Cl}$ and the base attacking the $\ce{H}$ will be on the same side. So will elimination be possible in this case?

An $E2$ (or $E1cb$) mechanism requires antiperiplanar configuration. In case of restricted rotations, like in cycles, where rotation is not possible to achieve the antiperiplanar configuration, elimination occurs to favour the Hofmann product instead of the Zaitsev, if antiperiplanar configuration is possible at the less substituted β C. In menthyl chloride,

enter image description here

antiperiplanar configuration is only seen with the red $\ce{H}$, so 2 menthene is the only product, although it is not the most substituted. In

enter image description here

again due to restricted rotation, the leaving group $\ce{Cl}$ and the base attacking the $\ce{H}$ will be on the same side. So will elimination be possible in this case?

An $\mathrm{E2}$ (or $\mathrm{E1cb}$) mechanism requires antiperiplanar configuration. In case of restricted rotations, like in cycles, where rotation is not possible to achieve the antiperiplanar configuration, elimination occurs to favour the Hofmann product instead of the Zaitsev, if antiperiplanar configuration is possible at the less substituted β C.

enter image description here

In menthyl chloride, antiperiplanar configuration is only seen with the red $\ce{H}$, so 2 menthene is the only product, although it is not the most substituted.

enter image description here

In the molecule above, due to restricted rotation, the leaving group $\ce{Cl}$ and the base attacking the $\ce{H}$ will be on the same side. So will elimination be possible in this case?

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user15489
user15489

An E2$E2$ (or E1cb$E1cb$) mechanism requires antiperiplanar configuration. In case of restricted rotations, like in cycles, where rotation is not possible to achieve the antiperiplanar configuration, elimination occurs to favour the Hofmann product instead of the Zaitsev, if antiperiplanar configuration is possible at the less substituted β C. In menthyl chloride,

enter image description here

antiperiplanar configuration is only seen with the red H$\ce{H}$, so 2 menthene is the only product, although it is not the most substituted. In

enter image description here

again due to restricted rotation, the leaving group Cl$\ce{Cl}$ and the base attacking the H$\ce{H}$ will be on the same side. So will elimination be possible in this case?

An E2 (or E1cb) mechanism requires antiperiplanar configuration. In case of restricted rotations, like in cycles, where rotation is not possible to achieve the antiperiplanar configuration, elimination occurs to favour the Hofmann product instead of the Zaitsev, if antiperiplanar configuration is possible at the less substituted β C. In menthyl chloride,

enter image description here

antiperiplanar configuration is only seen with the red H, so 2 menthene is the only product, although it is not the most substituted. In

enter image description here

again due to restricted rotation, the leaving group Cl and the base attacking the H will be on the same side. So will elimination be possible in this case?

An $E2$ (or $E1cb$) mechanism requires antiperiplanar configuration. In case of restricted rotations, like in cycles, where rotation is not possible to achieve the antiperiplanar configuration, elimination occurs to favour the Hofmann product instead of the Zaitsev, if antiperiplanar configuration is possible at the less substituted β C. In menthyl chloride,

enter image description here

antiperiplanar configuration is only seen with the red $\ce{H}$, so 2 menthene is the only product, although it is not the most substituted. In

enter image description here

again due to restricted rotation, the leaving group $\ce{Cl}$ and the base attacking the $\ce{H}$ will be on the same side. So will elimination be possible in this case?

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Charles
Charles
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Anti elimination from vinylic halides

An E2 (or E1cb) mechanism requires antiperiplanar configuration. In case of restricted rotations, like in cycles, where rotation is not possible to achieve the antiperiplanar configuration, elimination occurs to favour the Hofmann product instead of the Zaitsev, if antiperiplanar configuration is possible at the less substituted β C. In menthyl chloride,

enter image description here

antiperiplanar configuration is only seen with the red H, so 2 menthene is the only product, although it is not the most substituted. In

enter image description here

again due to restricted rotation, the leaving group Cl and the base attacking the H will be on the same side. So will elimination be possible in this case?