The purposeful execution of chemical reactions to obtain a desired product.

learn more… | top users | synonyms

3
votes
0answers
22 views

Where can I obtain research material on the synthesis of polypyrrole?

I'm studying Chemistry at A-level and a large part of the course is a researcher paper that takes most of the year. Conductive polymers interest me. I'm struggling to find any surfeited researcher on ...
2
votes
3answers
85 views

Produce CuCl2 from CuSO4

I have a large amount of copper sulfate available and I am interested in obtaining copper chloride from it. What is the easiest way to do so? I have considered mixing an aqueous solution of copper ...
4
votes
1answer
51 views

How to deprotect a benzyl ether? (Birch reduction)

I'd like to deprotect a benzyl group for a Frater Seebach alkylation (see also: How can a ketone selectively be reduced? (Frater Seebach Alkylation)). Will the first reaction with $\ce{Li/NH3}$ ...
4
votes
1answer
39 views

How can a ketone selectively be reduced? (Frater Seebach Alkylation)

I'd like to reduce enantioselectively a ketone in presence of an ester (which should NOT be reduced to an aldehyde and further to an alcohol). Adding $\ce{LiAlH4}$ would also reduce the ester and ...
4
votes
1answer
33 views

Cyclopentyl to cyclohexyl carbocation rearrangement

Here is my problem. The mechanism seems pretty straightforward, but I am having trouble converting the cyclopentane to a cyclohexane. During a synthesis problem, does the starting material add the ...
4
votes
1answer
75 views

Synthesis of Oxalyl Chloride without using Phosphorus

I have been synthesizing TCPO (for chemiluminescent reaction) using 2,4,6 trichlorophenol and oxalyl chloride. Since I am tired of paying for oxalyl chloride (and hazard class 3 shipping), I wish to ...
5
votes
0answers
26 views

Seeking titanium compound, melting point <1600 °C, decomposes to TiO

The title says it all. I’m new to glass making, and I need a titanium compound that will render me $\ce{TiO}$ through decomposition, and has a melting point under 1600 °C. Hopefully I can get one ...
2
votes
0answers
24 views

Graph of compounds/reactions used on the industrial scale

I'm looking for a machine-readable database describing industrially useful reactions in terms of inputs, outputs, and (possibly) catalyzers etc. for a large portion of, or (much more preferable) the ...
2
votes
1answer
70 views

Making carbon monoxide gas from formic acid and sulphuric acid?

Can I create carbon monoxide gas by just mixing formic acid and sulphuric acid together. Or do they have to be heated?
4
votes
1answer
49 views

Why is tert-Butyl (tBu) often not listed as protecting group for alcohol?

I am not seing tBu listed as alcohol protection group in all of these places: https://en.wikipedia.org/wiki/Protecting_group#Alcohol_protecting_groups http://www.synarchive.com/protecting-group/ ...
8
votes
2answers
287 views

Getting 3,4-dimethylhex-3-ene from but-2-ene

How can one get 3,4-dimethylhex-3-ene from but-2-ene ? $\hskip2in$ Using $\ce{Br_2}$ then two equivalents of $\ce{CH_3CH_2MgBr}$, I can get the corresponding alkane (3,4-dimethylhexane) but I don't ...
11
votes
1answer
122 views

Byproducts in Indigo Synthesis?

I have been messing around with making Indigo dye while waiting for bacteria to grow. I have been following the Baeyer-Drewson method. Basically, you mix nitrobenzaldehyde with an acetone water mix ...
1
vote
1answer
85 views

Synthesis of phenoxyacetone from phenol

How can phenoxyacetone be synthesized from phenol? My Attempt: We would first need to deprotonate phenol by addition of NaH in THF and then add bromopropene. I'm not quite sure where I would go ...
6
votes
1answer
108 views

Search for the last step of an altered Raschig process reaction mechanism

The Raschig process (according to the german wikipedia) is divided in the following steps: $\ce{2NaOH + Cl2 -> NaOCl + NaCl + H2O}$ $\ce{NaOCl + H2O -> HOCl + NaOH}$ $\ce{HClO + NH3 -> ...
2
votes
1answer
38 views

What makes many water soluble fertilizers blue?

I've noticed that water soluble fertilizers tend to be blue. What chemicals or chemical reactions cause this color here? Is this necessary or for aesthetic purposes? I haven't seen this in organic ...
5
votes
1answer
33 views

Stereochemistry of epoxide hydrolysis under acidic conditions

The epoxide on the top of the picture, in aqueous acid hydrolyzes to the compound below. What is the mechanism of this reaction? Standard epoxide opening in acidic conditions would happen at the more ...
1
vote
0answers
39 views

Permanganate Oxidation Process [closed]

I need articles where aryl ketones are converted using permanganate. Other articles which will lead to oxidation of aryl ketones to benzoic acid will also be helpful to me.
0
votes
1answer
32 views

The difference between the different types of rhodamine

What is the difference between different type of rhodamine, for example rhodamine red and rhodamine green? are these two type of rhodamine (red & green) have a good Raman signal? We would like ...
2
votes
0answers
31 views

Calculating yield percentage of magnetite synthesis

I’ve made magnetite $\ce{Fe3O4}$ in the lab and now I need to calculate yield percentage. How can I do it? I have these data. \begin{align} \ce{FeSO4.7H2O(aq) &-> Fe^2+(aq) + SO4^2- (aq) + ...
5
votes
0answers
35 views

Can I make Ferrofluid without evaporating Ammonium?

I want to make ferrofluid, which is ferromagnetic particles suspended in a carrier fluid. Three methods I have seen involve using magnetic ink (for MICR codes), cassette tapes, or ferric chloride as ...
11
votes
3answers
747 views

Why is solid phase peptide synthesis limited to 70 amino acids?

I'm reading document about Solid phase protein synthesis (SPPS) from Wikipedia, and according to the document: SPPS is limited by yields, and typically peptides and proteins in the range of 70 ...
5
votes
1answer
62 views

how to destroy excess iodomethane in reaction mixture?

I have used iodomethane to make a phenolic $\ce{OH}$ group to $\ce{OMe}$ group in Aq+Methanol medium. I have added water to precipitate the product of mine and will evaporate the solvents but I cant ...
6
votes
2answers
88 views

Synthesis Challenge

I have been trying to make a monomer reached a dead end in the middle. A B C are the products I have made so far respective order. After reaching C I wanted to prepare 2 but could not find a way to ...
9
votes
3answers
205 views

Industrial synthesis of hydrazine

Not a duplicate of Hydrazine synthesis - I know what hydrazine is and am not going near it voluntarily! Looked at this resource on the Internet which cites three major commercial-scale processes: ...
0
votes
0answers
55 views

Evaporation of acetic acid

I performed aan acid catalysed haloform reaction in acetic acid to an acid. I need to evaporate acetic acid which I used as solvent and It is around 150 ml. What are the alternatives , I have a ...
0
votes
1answer
65 views

Haloform reaction in acidic condition

I want to know about the reaction mechanism of haloform reaction in acidic condition. I am following a persons doctoral thesis where he used acid medium haloform reaction but unfortunately he has not ...
2
votes
0answers
42 views

How to perform oxidation of keto group in presence of hydroxyl group?

How to perform oxidation of keto group in presence of hydroxyl group. I fear there may be halogenation at $\ce{OH}$ group. Is there a way to protect the $\ce{OH}$ group ?
1
vote
0answers
32 views

Solublity of esters in Dichloromethane?

Are esters soluble in Dichloromethane? I have a ketone with methyl group at one end and on the other end a big biphenyl group with a 6 carbon long aliphatic chain at 4'. I am planning to oxidise the ...
1
vote
1answer
132 views

How to prepare potassium cyanide from potassium ferrocyanide

How do we prepare potassium cyanide from potassium ferrocyanide? It is something which I am curious about, but cannot find the answer. I am studying inorganic chemistry but this reaction cannot be ...
3
votes
1answer
103 views

What are the steps to creating synthetic glucose?

I need to know how to go about creating synthetic glucose with generally available materials. As I am aware of both photosynthesis and glucose in nature, I will not need lessons in how plants produce ...
7
votes
1answer
61 views

Selective alkylation of carboxylic acid vs. phenol

A is the reactant and b is the product. There are two couplings to be done. 1 and 2. Which sequence should be followed, ie. 1 should be coupled first or 2 should be coupled first? for coupling 1 , ...
5
votes
0answers
194 views

Clemmensen reduction vs. Wolff-Kishner reduction

In which cases is the Clemmensen reduction is preferred over the Wolff-Kishner reduction? One thing is that the Clemmensen reduction is done under acidic conditions whereas the Wolff-Kishner ...
2
votes
1answer
72 views

Grignards and anhydrous ethanol

I remember using both 95% ethanol and absolute ethanol quite a few times. You'd need absolute ethanol for a reaction that would fail if water was present, such as a Grignard reaction. I can't ...
4
votes
1answer
70 views

Preparation of 6-bromo-1-hexanol

I am refluxing $\ce{HBr}$ with 1,6-hexanediol for 16 hours at $80\ ^\circ\mathrm{C}$ in toluene. How can I be sure that more than $90\,\%$ of the product is brominated only at one terminal? If the ...
4
votes
1answer
56 views

Ketone to alkene regiochemistry

What are the reagents for the following reactions: Typically, when thinking about ketone to alkene reactions, one thinks of the Wittig reaction. However, I don't see an appropriate form of that ...
1
vote
1answer
27 views

Can 4-pyridones be synthesised analogously to 2-pyridones?

I understand that 2-pyridone derivatives can be synthesized by oxidizing an N-methyl pyridinium salt with $\ce{[Fe(CN)6]^3-}$ under basic conditions. Can a similar method be used to produce ...
3
votes
1answer
52 views

Possible Synthesis of a Polymer

Following a question I have asked previously, what I intend to inquire this time is quite similar as well, except, with a polymer. So previously I asked whether such monomer PCDO is possible to ...
13
votes
1answer
91 views

Interlocked Cyclic Compounds

Being new to chemistry, there may ought to be some properties I couldn't understand fully. One of them being cyclic compounds. One particular question about this is, whether these cyclic compounds, ...
5
votes
1answer
66 views

Method of deriving some properties or possible method of synthesis of a specific monomer

This is kind of like two questions but since they're related I have put them together. Consider a monomer under a hopefully anatomically correct name 'Phenyl Carbolithia Divinylene Oxide ...
2
votes
1answer
102 views

Synthesis of bromobutane

What will be the cost efficient and high yielding method of synthesis for 1-bromobutane? I can react butanol with $\ce{HBr}$ but I am worried butanol is not present at the moment in lab. But I need ...
16
votes
1answer
119 views

Propose a chemical formula for the white solid that forms during the initial stages of the reaction of Sn with benzyl chloride

In my inorganic class, we carried out the synthesis of Chlorotribenzyltin, $\ce{SnCl(CH2C6H5)3}$. The synthesis begins with a reflux I'll describe below: In a hood, place 2.0 g (17 mmol) of 325 ...
6
votes
1answer
83 views

How to reduce an acyl group on a benzene without disturbing nitro group

Is it possible to reduce an acyl group to an alkane, but still keep a nitro group intact without its reduction to an amino group. A Clemmensen reduction would reduce the nitro group and it seems like ...
5
votes
1answer
236 views

Is it possible to oxidize ether to ester?

Is it possible to synthesize ester from an ether directly (only one step)? For example if I had an ether $\ce{(R-CH2-OR')}$ and oxidize it so it will be an ester $\ce{(R-CO-OR')}$.
5
votes
1answer
212 views

Nitration of pyrrole

Would 2,5-dinitropyrrole be a product of nitration of pyrrole with $\ce{H2SO4/HNO3}$ ? It seems from this paper that it is not formed using acetic anhydride/nitric acid. Is this just because of the ...
4
votes
2answers
158 views

Origin of alkenes from Wurtz Reaction

According to Wikipedia: Also, since the reaction involves free radical species, a side reaction occurs to produce an alkene. This side-reaction becomes more significant when the alkyl halides are ...
5
votes
1answer
93 views

Clemmensen reduction of 1,3 diketones

As part of a synthesis I was considering the following reaction: How selective is the Clemmensen reduction? I know that the Clemmensen reduction favours ketones adjacent to benzene rings but will ...
3
votes
1answer
62 views

Mechanism of enolether formation with ethyl orthoformate in estr-4-ene-3,17-dione (Djerassi's norethisterone synthesis)

The second step of Djerassi's synthesis of 19-nor-17α-ethynyltestosterone (norethindrone), involves the protection of the ketone in position 3 via enolether formation, as in the picture: What is ...
0
votes
1answer
147 views

Why might the O—H stretch in the IR of MY triphenylmethanol product be less intense than expected?

Why might the O—H stretch in the IR of MY triphenylmethanol product be less intense than expected when compared to the expected IR for triphenylmethanol? I'm interpreting the IR I took of my product, ...
6
votes
1answer
139 views

Synthesis of ethyl methyl ketone from 2-(4-hydroxyphenyl)ethyl methyl ketone

Is it possible to reduce raspberry ketone (4-(4-Hydroxyphenyl)butan-2-one) to ethyl methyl ketone? How would I do this in practice?
6
votes
2answers
90 views

Why can you not make a compound with a quaternary alpha carbon using malonic ester?

So my textbook tells me that using malonic ester to make a quaternary alpha carbon is impossible (I get that this might be hyperbole). However, it doesn't explain why and I don't understand why. My ...