Applies to long and complex natural product syntheses as much as to short one or two-step syntheses. This also covers synthetic problem sets and retrosynthetic analyses. Should not be applied to simple reactions such as the formation of hydrogen by acidic oxidation of metals.

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Synthesis of Polyvinylidene fluoride (PVDF)

I would like to know what the easiest way of synthesising PVDF is, or is it easier to buy the polymer online, and could PVDF be made transparent. Thanks
4
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2answers
52 views

Method to synthesize KAu(CN)2 (or KCN)?

Every reasonably effective method of electroplating $\ce{Au}$ onto another metal's surface (e.g. $\ce{Cu}$,$\ce{Ni}$,$\ce{Ag}$, etc.) involves use of $\ce{KAu(CN)2}$ or in some cases $\ce{KAu(CN)4}$ ...
4
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1answer
81 views

How to synthesise 2-aminoethyl benzene

Starting with benzene, describe the synthesis of 2-phenylethan-1-amine providing all the reagents and conditions. I am not really great at organic chemistry and my knowledge is pretty limited. ...
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0answers
25 views

Argireline: Acetyl Hexapeptide 3 - Harmful cosmetics?

Background I came across a friend that told me about Jeunesse Global he has started working with. This company (multi level marketing) sells cosmetic products that seem to be not really in line with ...
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0answers
25 views

KMnO4 Oxidation of Methyl Group Attached to Nitrogen

Is it possible for a methyl group directly attached to a nitrogen atom in a non-aromatic compound $\left(\ce{-N-CH3}\right)$ to be oxidized using $\ce{KMnO4}$ in acidic medium to form a corresponding ...
7
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0answers
56 views

Enolate formation in cis/trans decalin

What will happen in the following reactions? I thought that after OH is converted into a good leaving group OTs, an enolate would be formed which would attack $CH_2OTs$, but the obtained structure ...
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2answers
61 views

Suggestions for reaction conditions to prepare methyl 2,4,6-trimethylbenzenesulfonate

I'm a beginner in organic chemistry and I wish to produce methyl 2,4,6-trimethylbenzenesulfonate. My reactants are 2,4,6-trimethylbenzenesulfonyl chloride (solid crystals) and methanol (solvent as ...
4
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0answers
62 views

What is the product after treating ethene successively with chlorine and water, sulfuric acid, and potassium hydroxide?

Question: Ethene reacts with $\ce{Cl2}$ in $\ce{H2O}$ to form A. A on reaction with $\ce{H2SO4}$ followed by heating gives B. B on reaction with alcoholic $\ce{KOH}$ gives C. Find C. My ...
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1answer
66 views

Corey -House synthesis vs Wurtz reaction

In Corey House synthesis the first step is formation of Alkyl Lithium. why can't we react alkyl lithium with alkyl halide to produce alkanes. Rather we choose to prepare Gilman's reagent? Does it have ...
7
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2answers
86 views

Simple method to lengthen alkane?

I'm working on a science project which involves the production of methane. I would like to be able to use the methane as fuel in (e.g.) cars (using octane) or gas tanks (using butane and propane) etc. ...
3
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1answer
49 views

Is this structure make-able?

I was wondering if it would be possible to make this chemical?
3
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1answer
138 views

Why is the Friedel-Crafts alkylation of nitrobenzene disfavoured?

Suggest a synthetic route to m-nitrotoluene, starting from benzene. The conversion can be achieved in two ways: $\hspace{10 mm}$ or: However, the first route is not possible as the ...
6
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2answers
127 views

Synthesize acyl chloride from aldehyde

I know it is usually easier to go from an acyl chloride to an aldehyde, but is there a way to synthesize acyl chlorides from an aldehyde? Edit: Upon some textbook reading (Wiley: Organic ...
2
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1answer
31 views

Using UV-C (254nm) light to cleave the amino acid off of vyvanse

Vyvanse: Desired product: Amide bonds absorb in the region of about 190 to 240 nm, so could using UV-C light conceivably cleave the amide bond? Also I don't think this reaction is as simple ...
2
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0answers
32 views

Tips for Improving Synthesis

I have already asked a similar question on titrations before. In a few months, I have a test on chemical synthesis. It is marked on the percentage yield, purity and crystal size of the product. I do ...
7
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1answer
98 views

Converting a cis-alkene to trans-alkene

I was thinking about simple method to convert a cis-alkene alkene like cis-2-butene to trans-2-butene. I came up with this method (the method can also be used to convert trans alkene to cis alkene): ...
0
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1answer
32 views

Is this a feasible synthetic route for 1-(phenylethynyl)cyclopentan-1-ol?

From my notes $\ce{NaNH_2}$ is a good base for the deprotonation of alkynes. After the deprotonation I thought the alkyne would attack the carbon on the cyclopentanone because of the $\delta^+$ ...
6
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0answers
56 views

Treating cyclic dihalide with xs NaNH2

I've come across the following problem in Klein's Organic Chemistry (2nd): However, I'm a little bit confused about why the terminal alkyne is produced, since the elimination is step wise (I ...
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2answers
112 views

How to synthesize 2-benzylcyclohexan-1-ol from cyclohexanone?

There are no conditions given and a mechanism is required. I first thought it could be along the lines of Clasien rearrangement but that needs an aromatic ring. Since the Clasien rearrangement can't ...
4
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1answer
74 views

Reactions of alcohol with sulfuric acid

I knew two chemical reactions of alcohol with sulfuric acid $\ce{CH3CH2OH + H2SO4 -> CH2CH2}$ Here product is having a double bond (ethene) and this reaction happens at 443 K temperature. ...
4
votes
1answer
96 views

Synthesis of 2-methyl-4-nitrophenol from benzene?

How could 2-methyl-4-nitrophenol be synthesized from benzene? Benzene first reacts with the reagents $\ce{CH3Cl/AlCl3}$, to attach a methyl ($\ce{CH3}$) group to the benzene ring. Then I suggested ...
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0answers
31 views

How do you find synthesis preparations quickly and efficiently? [closed]

I started working in a synthesis lab as a undergraduate researcher, and my PI often asks me to find preparations for how to make certain compounds. I was wondering if anyone had any tricks for ...
9
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1answer
122 views

Double alkylation of benzene to form ring

I have been asked to suggest a synthesis for the following compound (tetralin) from benzene: I am unsure how to do this. It surely can't be Friedel-Craft alkylation because of carbocation ...
2
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0answers
69 views

Mechanism of the Synthesis of Cyclooctatetraene from Pseudopelletierine [closed]

We've been looking at total synthesis in class and the uses of the products. An example was Willstätter's use of pseudopelletierine to synthesise cyclooctatetraene. I've just been wondering how ...
4
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1answer
170 views

Converting an Alcohol to Alkyl Chloride (Ibuprofen)

In the synthesis of Ibuprofen you can shake 1-(4-Isobutylphenyl)ethanol to produce 1-Chloro-1-(4-isobutylphenyl)ethane $\hspace{7 mm}$ In a separatory funnel at room temperature. Usually its only ...
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2answers
65 views

How can I prepare Cu2S powder?

How can I prepare $\ce{Cu2S}$ powder? I have some idea about preparing the ternary composition containing copper,but copper sulfides are difficult due to the large difference between their melting ...
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2answers
36 views

Can hemi-acetal rings form under basic conditions?

I recently encountered a problem on a test. It was a standard synth problem, "Provide reagents to produce y from x". The starting material was DHA and the ending molecule was a branched pentose. (I ...
4
votes
1answer
102 views

Solid phase peptide synthesis (SPPS): why does capping after each coupling improve results?

The title more or less sums up my questions: why does capping after coupling improve results during solid phase peptide synthesis (SPPS)? The Case: I have conduced a lab experiment where we coupled ...
2
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0answers
29 views

The effect of tetrahydrofuran solvent [closed]

We prepared the PhTeNa in situ from (PhTe)2 and sodium wire in THF. can we change the THF solvent by an other solvent having the same effect.
3
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1answer
125 views

The difference between one pot synthetic method and one step reaction

I often read in the papers of organic synthesis that the reactions can be carried out in one-pot method, and the others can be realized in one-step. I want to know the difference between one pot and ...
2
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0answers
200 views

Mechanism for synthesis of 4-nitrophenylhydrazine from the diazonium salt of 4-nitroaniline

I am trying to figure out the mechanism to create 4-nitrophenylhydrazine from the diazonium salt of 4-nitroaniline. I've found a couple of explanations for what reactants are used, but I don't ...
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1answer
48 views

I found instructions on how to make nerve gas. Is it possible to be real? [closed]

dear chemists! I just happened to find instructions how to make nerve gas. I found it on the Deep web. And since I know next to nothing about chemistry, I'm gonna ask here: Is it possible to make ...
2
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0answers
32 views

Shelf Life of Methylcyclopentadiene

We are making organometallics in the lab, but instead of just regular Cyclopentadiene dimer, we crack methylcyclopentadiene dimer to make methylcyclopentadiene. I cannot find the shelf life of ...
1
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1answer
42 views

Can I melt Barium Titanate powder into a cylinder and preserve the high dielectric?

I would like to make various solid forms of Barium Titanate e.g. cylinders, discs. Barium Titanate powder seems widely available and has a melting point of 1,625'C. Can I melt it in an iron forge ...
4
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0answers
42 views

Elucidating reaction mechanism and purpose

Please help me understand synthesis sequence shown below: Benzylbromide is used for protection, probably form action of $\ce{CuBr2}$, but it's reaction mechanism is unknown for me. The bromination of ...
4
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1answer
52 views

Stereochemistry of product in Diels-Alder reaction

I have a few questions on this problem I solved: 1) Why does carbon "b" on methyl vinyl ketone attack carbon "5" on the lactone? Why not carbon "2"? 2) The answer key says that the end product ...
4
votes
1answer
88 views

In the Wittig reaction, why do stabilised ylides produce E-alkenes and unstabilised ylides produce Z-alkenes?

Wikipedia says that with unstabilised ylides they react very quickly in step 1-2 and step 4-5 is the rate limiting step. But with stabilised ylides step 1-2 is the rate limiting step and this is why ...
2
votes
1answer
74 views

Effectiveness of Grignard reagent

So for my experiment, I am synthesizing grignard's reagent (phenylmagnesium bromide). I am trying to change the dryness of ether and see if there is a change in products. Is there a simple method to ...
5
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1answer
260 views

Convert benzene to isopropylbenzene

Which of the following reagents will convert benzene to isopropylbenzene? Choose all that are appropriate. I know for certain that (b) can be used, but I also think the following mechanism with ...
1
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0answers
61 views

How to make the 1,2 dinitrobenzene synthesis with benzene at the beginning?

I want to make the synthesis of 1,2 dinitrobenzene only without find 1,3 and 1,4. In my synthesis I have a step in which I obtain aniline, I would like to know the mechanism of the proctetion of it ...
3
votes
2answers
179 views

N-alkylation of amides with alkyl halides?

Can amides be N-alkylated with alkyl halides? Say I was trying to make N-propyl acetamide. Would iodopropane and acetamide react to form it? Would they react to form N,N-dipropyl acetamide? If so, ...
1
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0answers
93 views

Best Method To Make Large Graphene Oxide Sheets?

There are so many methods to make graphene oxide now, I'm not exactly experienced enough to know which is ideal. I want to know what the best method is for making large graphene oxide membranes. The ...
6
votes
1answer
108 views

What does the “h” “k” and “(5.2.2.02,6)” mean in Dibenzo(h,k)-4-oxatricyclo(5.2.2.02,6)undec-8,10- diene-3, 5-dione

I am preparing to do an experiment that involves synthesizing Dibenzo(h,k)-4-oxatricyclo(5.2.2.02,6)undec-8,10- diene-3, 5-dione via a Diels-Alder reaction. Could someone please explain the ...
2
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0answers
28 views

What is the appropriate sizing for fiberglass compatible with polyamide?

I am looking for a chemical coating for glass A fibers, compatible with polyamide. The fibers are uncoated, 100-filament strands of 22-micrometer "A" glass fibers. We are producing fiberglass in our ...
8
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2answers
207 views

Choice of base for malonic ester synthesis

Most reaction mechanisms use $\ce{EtO-}$ as a base to deprotonate the alpha hydrogen in the malonic ester sythesis. But in the equilibrium there are still esters that haven't been deprotonated. Why ...
4
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0answers
52 views

How to esterify phenol with oxalic acid?

Is it possible to fully esterify phenol with oxalic acid in order to get diphenyl oxalate? What catalyst to use and is the synthesis possible to perform at home with hobby equipment?
6
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1answer
53 views

Synthesis using Cationic Hetero-Cope Rearrangement

By searching for the reference of the synthesis below I arrived at an example of Cationic Hetero-Cope Rearrangement, but I can't access the paper. How does it work here, and what happens in the first ...
1
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1answer
477 views

Methods to prepare lactic acid from acetaldehyde

I got one method [here](using acetaldehyde and carbon monoxide)1. But is there any alternative method (using specific catalyst)?
3
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1answer
346 views

How to convert ethanol to 1,1-dichloroethane?

How to convert ethanol to 1,1-dichloroethane? My approach: Convert ethanol to ethene followed by $\ce{HCl}$ addition. But that's no use. Well if it is possible to create gem-diol from here, then ...
3
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1answer
72 views

Methyl Iodide synthesis

I was trying to determine whether I could synthesize methyl iodide by combining methanol, potassium iodide and sulphuric acid together... The way I see it, the sulphuric acid will protonate the OH ...