The purposeful execution of chemical reactions to obtain a desired product.

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Methods to prepare lactic acid from acetaldehyde

I got one method [here](using acetaldehyde and carbon monoxide)1. But is there any alternative method (using specific catalyst)?
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1answer
202 views

How to convert ethanol to 1,1-dichloroethane?

How to convert ethanol to 1,1-dichloroethane? My approach: Convert ethanol to ethene followed by $\ce{HCl}$ addition. But that's no use. Well if it is possible to create gem-diol from here, then ...
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1answer
24 views

Methyl Iodide synthesis

I was trying to determine whether I could synthesize methyl iodide by combining methanol, potassium iodide and sulphuric acid together... The way I see it, the sulphuric acid will protonate the OH ...
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10 views

How does Glucose synthesis via the Kiliani-Fischer reaction work? [closed]

Synthetise glucose from D-1,3 dihydroxy aldehyde propanal.
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2answers
46 views

How to synthesise (E)-5-methylhex-3-en-2-one via a Wittig reaction?

I am trying to understand the Wittig reaction and am having difficulties in bringing all the information together to answer a question. I have been asked to synthesize compound A: The question asks ...
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0answers
50 views

Synthesizing 2-methyl-2-butanol

I have recently been trying to come up with a method to create 2-methyl-2-butanol or tert-amyl alcohol. I wanted to avoid complex/expensive steps since as a home chemist/student, I don't have access ...
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36 views

Why use potassium iodide instead of copper iodide in Sandmeyer reaction?

The Sandmeyer reaction is an extremely useful reaction for the functionalization of aromatic rings through a diazonium intermediate. For conversion of a diazonium intermediate to the corresponding ...
2
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1answer
32 views

Organic conversion: benzene to 3-bromoiodobenzene

Today, my chemistry teacher gave the organic conversion as homework. Benzene to 3-bromoiodobenzene I tried something like: I am not sure about it, can someone review my conversion (as I have got ...
3
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0answers
29 views

Where can I obtain research material on the synthesis of polypyrrole?

I'm studying Chemistry at A-level and a large part of the course is a researcher paper that takes most of the year. Conductive polymers interest me. I'm struggling to find any surfeited researcher on ...
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3answers
131 views

Produce CuCl2 from CuSO4

I have a large amount of copper sulfate available and I am interested in obtaining copper chloride from it. What is the easiest way to do so? I have considered mixing an aqueous solution of copper ...
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1answer
65 views

How to deprotect a benzyl ether? (Birch reduction)

I'd like to deprotect a benzyl group for a Frater Seebach alkylation (see also: How can a ketone selectively be reduced? (Frater Seebach Alkylation)). Will the first reaction with $\ce{Li/NH3}$ ...
5
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1answer
53 views

How can a ketone selectively be reduced? (Frater Seebach Alkylation)

I'd like to reduce enantioselectively a ketone in presence of an ester (which should NOT be reduced to an aldehyde and further to an alcohol). Adding $\ce{LiAlH4}$ would also reduce the ester and ...
4
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1answer
36 views

Cyclopentyl to cyclohexyl carbocation rearrangement

Here is my problem. The mechanism seems pretty straightforward, but I am having trouble converting the cyclopentane to a cyclohexane. During a synthesis problem, does the starting material add the ...
4
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1answer
98 views

Synthesis of Oxalyl Chloride without using Phosphorus

I have been synthesizing TCPO (for chemiluminescent reaction) using 2,4,6 trichlorophenol and oxalyl chloride. Since I am tired of paying for oxalyl chloride (and hazard class 3 shipping), I wish to ...
5
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0answers
33 views

Seeking titanium compound, melting point <1600 °C, decomposes to TiO

The title says it all. I’m new to glass making, and I need a titanium compound that will render me $\ce{TiO}$ through decomposition, and has a melting point under 1600 °C. Hopefully I can get one ...
2
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0answers
26 views

Graph of compounds/reactions used on the industrial scale

I'm looking for a machine-readable database describing industrially useful reactions in terms of inputs, outputs, and (possibly) catalyzers etc. for a large portion of, or (much more preferable) the ...
2
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1answer
130 views

Making carbon monoxide gas from formic acid and sulphuric acid?

Can I create carbon monoxide gas by just mixing formic acid and sulphuric acid together. Or do they have to be heated?
4
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1answer
64 views

Why is tert-Butyl (tBu) often not listed as protecting group for alcohol?

I am not seing tBu listed as alcohol protection group in all of these places: https://en.wikipedia.org/wiki/Protecting_group#Alcohol_protecting_groups http://www.synarchive.com/protecting-group/ ...
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2answers
303 views

Getting 3,4-dimethylhex-3-ene from but-2-ene

How can one get 3,4-dimethylhex-3-ene from but-2-ene ? $\hskip2in$ Using $\ce{Br_2}$ then two equivalents of $\ce{CH_3CH_2MgBr}$, I can get the corresponding alkane (3,4-dimethylhexane) but I don't ...
12
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1answer
131 views

Byproducts in Indigo Synthesis?

I have been messing around with making Indigo dye while waiting for bacteria to grow. I have been following the Baeyer-Drewson method. Basically, you mix nitrobenzaldehyde with an acetone water mix ...
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1answer
92 views

Synthesis of phenoxyacetone from phenol

How can phenoxyacetone be synthesized from phenol? My Attempt: We would first need to deprotonate phenol by addition of NaH in THF and then add bromopropene. I'm not quite sure where I would go ...
6
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1answer
116 views

Search for the last step of an altered Raschig process reaction mechanism

The Raschig process (according to the german wikipedia) is divided in the following steps: $\ce{2NaOH + Cl2 -> NaOCl + NaCl + H2O}$ $\ce{NaOCl + H2O -> HOCl + NaOH}$ $\ce{HClO + NH3 -> ...
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1answer
43 views

What makes many water soluble fertilizers blue?

I've noticed that water soluble fertilizers tend to be blue. What chemicals or chemical reactions cause this color here? Is this necessary or for aesthetic purposes? I haven't seen this in organic ...
5
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1answer
35 views

Stereochemistry of epoxide hydrolysis under acidic conditions

The epoxide on the top of the picture, in aqueous acid hydrolyzes to the compound below. What is the mechanism of this reaction? Standard epoxide opening in acidic conditions would happen at the more ...
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0answers
40 views

Permanganate Oxidation Process [closed]

I need articles where aryl ketones are converted using permanganate. Other articles which will lead to oxidation of aryl ketones to benzoic acid will also be helpful to me.
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1answer
35 views

The difference between the different types of rhodamine

What is the difference between different type of rhodamine, for example rhodamine red and rhodamine green? are these two type of rhodamine (red & green) have a good Raman signal? We would like ...
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0answers
36 views

Calculating yield percentage of magnetite synthesis

I’ve made magnetite $\ce{Fe3O4}$ in the lab and now I need to calculate yield percentage. How can I do it? I have these data. \begin{align} \ce{FeSO4.7H2O(aq) &-> Fe^2+(aq) + SO4^2- (aq) + ...
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52 views

Can I make Ferrofluid without evaporating Ammonium?

I want to make ferrofluid, which is ferromagnetic particles suspended in a carrier fluid. Three methods I have seen involve using magnetic ink (for MICR codes), cassette tapes, or ferric chloride as ...
12
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3answers
793 views

Why is solid phase peptide synthesis limited to 70 amino acids?

I'm reading document about Solid phase protein synthesis (SPPS) from Wikipedia, and according to the document: SPPS is limited by yields, and typically peptides and proteins in the range of 70 ...
5
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1answer
71 views

how to destroy excess iodomethane in reaction mixture?

I have used iodomethane to make a phenolic $\ce{OH}$ group to $\ce{OMe}$ group in Aq+Methanol medium. I have added water to precipitate the product of mine and will evaporate the solvents but I cant ...
6
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2answers
90 views

Synthesis Challenge

I have been trying to make a monomer reached a dead end in the middle. A B C are the products I have made so far respective order. After reaching C I wanted to prepare 2 but could not find a way to ...
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3answers
215 views

Industrial synthesis of hydrazine

Not a duplicate of Hydrazine synthesis - I know what hydrazine is and am not going near it voluntarily! Looked at this resource on the Internet which cites three major commercial-scale processes: ...
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68 views

Evaporation of acetic acid

I performed aan acid catalysed haloform reaction in acetic acid to an acid. I need to evaporate acetic acid which I used as solvent and It is around 150 ml. What are the alternatives , I have a ...
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1answer
75 views

Haloform reaction in acidic condition

I want to know about the reaction mechanism of haloform reaction in acidic condition. I am following a persons doctoral thesis where he used acid medium haloform reaction but unfortunately he has not ...
2
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0answers
46 views

How to perform oxidation of keto group in presence of hydroxyl group?

How to perform oxidation of keto group in presence of hydroxyl group. I fear there may be halogenation at $\ce{OH}$ group. Is there a way to protect the $\ce{OH}$ group ?
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0answers
40 views

Solublity of esters in Dichloromethane?

Are esters soluble in Dichloromethane? I have a ketone with methyl group at one end and on the other end a big biphenyl group with a 6 carbon long aliphatic chain at 4'. I am planning to oxidise the ...
1
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1answer
280 views

How to prepare potassium cyanide from potassium ferrocyanide

How do we prepare potassium cyanide from potassium ferrocyanide? It is something which I am curious about, but cannot find the answer. I am studying inorganic chemistry but this reaction cannot be ...
3
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1answer
123 views

What are the steps to creating synthetic glucose?

I need to know how to go about creating synthetic glucose with generally available materials. As I am aware of both photosynthesis and glucose in nature, I will not need lessons in how plants produce ...
7
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1answer
67 views

Selective alkylation of carboxylic acid vs. phenol

A is the reactant and b is the product. There are two couplings to be done. 1 and 2. Which sequence should be followed, ie. 1 should be coupled first or 2 should be coupled first? for coupling 1 , ...
5
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1answer
274 views

Clemmensen reduction vs. Wolff-Kishner reduction

In which cases is the Clemmensen reduction is preferred over the Wolff-Kishner reduction? One thing is that the Clemmensen reduction is done under acidic conditions whereas the Wolff-Kishner ...
2
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1answer
86 views

Grignards and anhydrous ethanol

I remember using both 95% ethanol and absolute ethanol quite a few times. You'd need absolute ethanol for a reaction that would fail if water was present, such as a Grignard reaction. I can't ...
4
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1answer
71 views

Preparation of 6-bromo-1-hexanol

I am refluxing $\ce{HBr}$ with 1,6-hexanediol for 16 hours at $80\ ^\circ\mathrm{C}$ in toluene. How can I be sure that more than $90\,\%$ of the product is brominated only at one terminal? If the ...
4
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1answer
63 views

Ketone to alkene regiochemistry

What are the reagents for the following reactions: Typically, when thinking about ketone to alkene reactions, one thinks of the Wittig reaction. However, I don't see an appropriate form of that ...
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1answer
28 views

Can 4-pyridones be synthesised analogously to 2-pyridones?

I understand that 2-pyridone derivatives can be synthesized by oxidizing an N-methyl pyridinium salt with $\ce{[Fe(CN)6]^3-}$ under basic conditions. Can a similar method be used to produce ...
3
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1answer
56 views

Possible Synthesis of a Polymer

Following a question I have asked previously, what I intend to inquire this time is quite similar as well, except, with a polymer. So previously I asked whether such monomer PCDO is possible to ...
15
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1answer
95 views

Interlocked Cyclic Compounds

Being new to chemistry, there may ought to be some properties I couldn't understand fully. One of them being cyclic compounds. One particular question about this is, whether these cyclic compounds, ...
5
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1answer
66 views

Method of deriving some properties or possible method of synthesis of a specific monomer

This is kind of like two questions but since they're related I have put them together. Consider a monomer under a hopefully anatomically correct name 'Phenyl Carbolithia Divinylene Oxide ...
2
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1answer
103 views

Synthesis of bromobutane

What will be the cost efficient and high yielding method of synthesis for 1-bromobutane? I can react butanol with $\ce{HBr}$ but I am worried butanol is not present at the moment in lab. But I need ...
17
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1answer
135 views

Propose a chemical formula for the white solid that forms during the initial stages of the reaction of Sn with benzyl chloride

In my inorganic class, we carried out the synthesis of Chlorotribenzyltin, $\ce{SnCl(CH2C6H5)3}$. The synthesis begins with a reflux I'll describe below: In a hood, place 2.0 g (17 mmol) of 325 ...
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1answer
93 views

How to reduce an acyl group on a benzene without disturbing nitro group

Is it possible to reduce an acyl group to an alkane, but still keep a nitro group intact without its reduction to an amino group. A Clemmensen reduction would reduce the nitro group and it seems like ...