The purposeful execution of chemical reactions to obtain a desired product.
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1answer
37 views
Where did the acac come from in Cr(acac)3 synthesis by CrCl3 reagent?
Those are the reactions:
$$\ce{(H2N)2CO + 3 H2O -> CO2 + 2 NH4+ + 2OH-}$$
$$\ce{CH3COCH2COCH3 + OH- -> acac- + H2O}$$
$$\ce{CrCl3.6H2O -> Cr3+ + 3Cl- + 6H2O}$$
$$\ce{Cr3+ + 3acac- -> ...
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votes
1answer
21 views
Can I synthesize salicylic acid from salycylaldehyde?
I have a homework set about synthesis. One of the questions is:
You have a bottle of salycylaldehyde. And you want to make salicylic acid from salicylaldehyde. You can use all reagents and ...
0
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1answer
56 views
What is octanamide used for?
I read a paper about enzyme-catalysed synthesis of octanamide.
What is octanamide used for?
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votes
1answer
31 views
Effect of substituting oxygen with sulfur in durg molecules
What sort of changes in the properties of organic or drug molecule can be anticipated if you substitute some or all of the oxygen atoms with sulphur atoms, and vice versa.
My interest in this ...
0
votes
1answer
58 views
How to transform a tertiary alcohol to a carboxyl?
I am trying to transform a lipid with a tertiary alcohol into a carboxylic acid.
More specifically, I want to convert to diplopterol (see below) into something homologous to cholesteryl hemisuccinate ...
2
votes
1answer
62 views
Can iproniazid be prepared by reacting isoniazid with 2-chloropropane?
I'm asking as I fear that the 2-chloropropane might react with the pyridine ring to form k-isopropylpridine-4-carbohydrazidine where k=2,3,5. Or that no reaction will take place.
Figure 1: ...
2
votes
2answers
38 views
How do you change the cis-trans isomerism of compounds?
I would like to know a general procedure for the synthesising cis isomers from their trans counterparts and vice versa.
1
vote
0answers
44 views
How, chemically, would you remove protruding phenyl groups?
How, chemically, would you remove protruding phenyl groups? I mean for instance in the molecule phenethylamine there's a phenyl group sticking out (or protruding) how would you go about removing this ...
2
votes
3answers
100 views
Is it possible to produce graphene out of air?
In theory you should be able to turn $\ce{CO2}$ to $\ce{CO}$ and then to $\ce{C}$ and connects all the C-atoms together to form graphene.
That should be possible, because plants do something similar, ...
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0answers
36 views
What's an Effective Software For Writing Out Synthesis Steps? [duplicate]
What's an effective Software For Writing Out Synthesis Steps that Works on Linux?
2
votes
1answer
20 views
What is the mechanism of functionalisation of nanoparticle using long chain alcohols
How can long chain alcohols(not thiols) be functionalised on the surface of silver or gold nanoparticles?
I have read in an article that Polyvinyl alcohol is used as a capping agent for silver ...
2
votes
1answer
54 views
How would you Synthesise LY-293,284?
How would I synthesise LY-293,284?
Figure 1: LY-293,284
I have satisfied the conditions at the page Should we allow Synthesis questions subject to the six constraints listed below? so please don't ...
2
votes
0answers
34 views
Primary amine versus phosphoramidate reactivity with succinate esters
I have posted two reactions below. The top reaction is well known and occurs readily and near quantitatively (e.g. in protein modification), while the bottom reaction to my knowledge does not exist in ...
0
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0answers
32 views
How would you Synthesise AR-R17? [closed]
I know this question seems very ill-conceived and explained so I'll try my best to improve on this. Basically I am interested in synthesising AR-R17 (see figure 1) from any substance that could be ...
0
votes
0answers
32 views
How would you synthesise Tropisetron from Indole? [closed]
As I said how would you synthesise tropisetron from indole. Here are the chemical structures if you require them to reason it out. Thanks for your time.
Figure 1: Indole
Figure 2: Tropisetron
...
1
vote
1answer
102 views
How do you Benzylate (add a benzene group to) cyclic compounds?
How do you add a benzene group to cyclic compounds like piperidine, piperazine and phenyl derivatives?
Piperidine
Piperazine
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votes
0answers
51 views
How would you Synthesise JZL184? [closed]
JZL184 is an irreversible and selective monoacylglycerol lipase inhibitor with its chemical structure below:
Figure 1: JZL184
I am at high school chemistry level of chemistry knowledge, I would ...
1
vote
1answer
29 views
How would you synthesise tetrahydrohyperforin and octahydrohyperforin from hyperforin?
The chemical structure of the compounds in question are:
Figure 1: Hyperforin
Figure 2: Tetrahydrohyperforin
Figure 3: Octahydrohyperforin
Would heating hyperforin in the presence of water ...
3
votes
1answer
25 views
How would you go about Synthesising Amino Sugars from Sugars?
How would you go about synthesising amino sugars from sugars? e.g. How would you synthesise the compound below from D-glucose?
Would adding ammonia (NH4) to it work?
2
votes
0answers
23 views
How do you Synthesise Glycosides of flavonoids and stilbenoids?
I would like to know how you go about synthesising glycosides of flavonoids and stilbenoids from their respective sugars and flavonoids/stilbenoids. I read ...
3
votes
2answers
127 views
How do you create primary amines from alcohols?
By a primary amine I mean a compound where the hydroxyl group of the corresponding alcohol is replaced with an amine group.
2
votes
2answers
68 views
Is it more reasonable to use stratification to separate similar compounds rather than using temperature?
In a simple reaction between butane and chlorine, it is more likely for the secondary carbons of the butane to lose a hydrogen and gain a chlorine. The carbocation is a more stable intermediate in ...
3
votes
1answer
58 views
Ambiguity synthesis
A paper says the following,
Dichloroglyoxime was prepared by chlorination of glyoxime in 10 % HCl at 0 deg C and crystallized from toluene.
When they say "crystallized from toluene" do they ...
0
votes
1answer
134 views
Why cannot HCN react with ethene?
I expected ethene ($\ce{C2H4}$) to undergo electrophilic substitution due to $\ce{HCN}$ but it doesn't happen, as I am told by my textbook.
I couldn't figure out the reason, as I found out that ...
1
vote
1answer
117 views
Reaction of acetic acid with alkylborane
I want the following conversion to take place$$\ce{Ph-R-CH2-BH2 -> Ph-R-CH3}$$ Does acetic acid react with the given alkyl borane to get this alkane? If yes, what is the correct mechanism? Please ...
0
votes
1answer
139 views
Hydrazine synthesis
I'm trying to make rocket fuel by hydrazine and hydrogen peroxide with home products my question is: Is there any way to synthesize hydrazine with bleach and ammonia, using $\ce{H2SO4}$ as a catalyst? ...
0
votes
0answers
53 views
How would one go about Synthesising AM404 in the lab?
AM404 or N-(4-hydroxyphenyl)arachidonoylethanolamide is one of the active metabolites of paracetamol (acetaminophen) and is biosynthesized by means of the enzyme, fatty acid amide hydrolase, ...
0
votes
1answer
112 views
Synthesis of nitrocellulose
I am trying to understand the synthesis of nitrocellulose.
A mixture of sulfuric acid and nitric acid is used to nitrate cellulose. The sulfuric acid acts as a catalyst, producing NO2+ ions from the ...
3
votes
1answer
87 views
How does one synthesise 2-Monoglycerides from Triglycerides?
How does one synthesise 2-monoglycerides from triglycerides with additional ingredients if necessary?
My first instinct would be to add a catalyst for the reaction of $triglyceride \rightarrow 3 FA + ...
3
votes
1answer
71 views
How do you Synthesise a Fatty Acid Amide?
How would you go about synthesising a fatty acid amide, preferably by means of a high-yield reaction. Please provide an explanation that I, as a grade 12 chemistry graduate, could understand.
I am ...
4
votes
2answers
290 views
Is it Possible to Synthesise Ethers from Carboxylic Acids?
Is it possible to synthesise ethers from carboxylic acids, and if so how? By ether I mean an ether in general (R-O-R'), not just specific examples.
I theorised one could perform Fischer ...
3
votes
4answers
160 views
Why are solid phase organics often conjugated to HCl?
Many uncharged organic compounds are sold in solid phase with HCl conjugate - e.g. the antihistamine diphenhydramine.HCl or the derivitizing agent pentafluorobenzyl hydroxylamine.HCl, among many ...
2
votes
1answer
38 views
Adenine precursor synthesis
I am currently exploring the synthesis of xRNA, which contains benzo-expanded purine and pyrimidines. I have found this paper which deals with exactly this subject, and provides the following ...
2
votes
1answer
400 views
Product of reaction. Dimedone and benzaldehyde
I'm having a hard time deducing the structure of product of dimedone and benzaldehyde in catalytic amount of piperidine. According to the manual first step proceeds via Knoevenegal reaction which ...
11
votes
1answer
172 views
What is the chemistry behind this “petrol from air” technology?
A recent news report in the UK claimed a breakthrough in making a petrol equivalent from carbon dioxide and water:
A small British company has produced the first "petrol from air" using a ...
7
votes
1answer
487 views
What is 'autogenous pressure'?
Compound 1 was hydrothermally synthesized under autogenous pressure[1]
I've seen this term used a few times, but with no real explanation of what it means forthcoming. I suspect it refers to the ...
4
votes
4answers
2k views
How to convert Carbon dioxide into Carbon and Oxygen?
How can $\small\cf{CO2}$ be converted into Carbon and Oxygen?
$\cf{CO2 -> C + O2}$
Alternatively:
$\cf{CO2 + ? -> C + O2}$
I know that plants are able to do this. But I'm wondering if it can ...
7
votes
1answer
237 views
Chemical synthesis via 3D printing?
I happened to stumble upon this Nature Chemistry article today. It claims that
[...] use a 3D printer to initiate chemical reactions by printing the reagents directly into a 3D reactionware ...
3
votes
0answers
158 views
Oxidative chlorination mechanism (sulfide to sulfonyl chloride)
I cannot find much guidance in the literature. Any ideas as to what the mechanism of this reaction might be?
2
votes
3answers
631 views
Synthesis of Chloroquine from 7-Chloro-3-Amino quinoline
Can we get Chloroquine from 7-chloro-3-aminoquinoline by adding $\ce{CH3CHCl(CH2)3N(Et)2}$ ?
6
votes
1answer
177 views
Is it possible that diamond can be grown from aqueous solutions?
Assume a cubic diamond crystal with hydrogen-terminated surface bonds. The terminating hydrogen atoms will form pairs that are geometrically close together in alternating diagonal pairs (think of the ...
9
votes
1answer
129 views
Stiffness of chewing gum
My Sister asked me this:
"Why is it that when we chew gum, it is soft and mushy to begin with , but slowly gets firmer and firmer like after 20 mins of chewing?"
I think it is because when we ...
3
votes
1answer
85 views
What is the geometric configuration of the four fluorine atoms during the synthesis of xenon tetrafluoride?
Neil Bartlett (1932–2008) first synthesized $\ce{XeF{_4}}$ (and $\ce{XeF{_6}}$) in 1962. In the synthesis, a nickel chamber is used, and heated to 400°C, causing the formation of $\ce{NiF{_4}}$, ...
5
votes
1answer
234 views
Acid catalysed synthesis of ethyl ethoxymethylenemalonate
One synthesis of quinolones begins with the formation of an ethyl ethoxymethylenemalonate, as seen in this Organic Syntheses paper.
I've been asked if the malonate derivative would be formed if ...
3
votes
2answers
126 views
Can recent developments improve the total synthesis of B-12?
The total synthesis of B-12 by Burns Woodward and Eschenmoser, is over 30 years old. At its time, it was considered a landmark in the field.
With current developments (e.g. olefin metathesis, ...
