The purposeful execution of chemical reactions to obtain a desired product.

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What makes many water soluble fertilizers blue?

I've noticed that water soluble fertilizers tend to be blue. What chemicals or chemical reactions cause this color here? Is this necessary or for aesthetic purposes? I haven't seen this in organic ...
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31 views

Stereochemistry of epoxide hydrolysis under acidic conditions

The epoxide on the top of the picture, in aqueous acid hydrolyzes to the compound below. What is the mechanism of this reaction? Standard epoxide opening in acidic conditions would happen at the more ...
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39 views

Permanganate Oxidation Process [closed]

I need articles where aryl ketones are converted using permanganate. Other articles which will lead to oxidation of aryl ketones to benzoic acid will also be helpful to me.
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1answer
20 views

The difference between the different types of rhodamine

What is the difference between different type of rhodamine, for example rhodamine red and rhodamine green? are these two type of rhodamine (red & green) have a good Raman signal? We would like ...
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29 views

Calculating yield percentage of magnetite synthesis

I’ve made magnetite $\ce{Fe3O4}$ in the lab and now I need to calculate yield percentage. How can I do it? I have these data. \begin{align} \ce{FeSO4.7H2O(aq) &-> Fe^2+(aq) + SO4^2- (aq) + ...
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27 views

Can I make Ferrofluid without evaporating Ammonium?

I want to make ferrofluid, which is ferromagnetic particles suspended in a carrier fluid. Three methods I have seen involve using magnetic ink (for MICR codes), cassette tapes, or ferric chloride as ...
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712 views

Why is solid phase peptide synthesis limited to 70 amino acids?

I'm reading document about Solid phase protein synthesis (SPPS) from Wikipedia, and according to the document: SPPS is limited by yields, and typically peptides and proteins in the range of 70 ...
5
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1answer
53 views

how to destroy excess iodomethane in reaction mixture?

I have used iodomethane to make a phenolic $\ce{OH}$ group to $\ce{OMe}$ group in Aq+Methanol medium. I have added water to precipitate the product of mine and will evaporate the solvents but I cant ...
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72 views

Synthesis Challenge

I have been trying to make a monomer reached a dead end in the middle. A B C are the products I have made so far respective order. After reaching C I wanted to prepare 2 but could not find a way to ...
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190 views

Industrial synthesis of hydrazine

Not a duplicate of Hydrazine synthesis - I know what hydrazine is and am not going near it voluntarily! Looked at this resource on the Internet which cites three major commercial-scale processes: ...
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46 views

Evaporation of acetic acid

I performed aan acid catalysed haloform reaction in acetic acid to an acid. I need to evaporate acetic acid which I used as solvent and It is around 150 ml. What are the alternatives , I have a ...
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54 views

Haloform reaction in acidic condition

I want to know about the reaction mechanism of haloform reaction in acidic condition. I am following a persons doctoral thesis where he used acid medium haloform reaction but unfortunately he has not ...
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38 views

How to perform oxidation of keto group in presence of hydroxyl group?

How to perform oxidation of keto group in presence of hydroxyl group. I fear there may be halogenation at $\ce{OH}$ group. Is there a way to protect the $\ce{OH}$ group ?
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26 views

Solublity of esters in Dichloromethane?

Are esters soluble in Dichloromethane? I have a ketone with methyl group at one end and on the other end a big biphenyl group with a 6 carbon long aliphatic chain at 4'. I am planning to oxidise the ...
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1answer
80 views

What are the steps to creating synthetic glucose?

I need to know how to go about creating synthetic glucose with generally available materials. As I am aware of both photosynthesis and glucose in nature, I will not need lessons in how plants produce ...
7
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1answer
53 views

Selective alkylation of carboxylic acid vs. phenol

A is the reactant and b is the product. There are two couplings to be done. 1 and 2. Which sequence should be followed, ie. 1 should be coupled first or 2 should be coupled first? for coupling 1 , ...
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94 views

Clemmensen reduction vs. Wolff-Kishner reduction

In which cases is the Clemmensen reduction is preferred over the Wolff-Kishner reduction? One thing is that the Clemmensen reduction is done under acidic conditions whereas the Wolff-Kishner ...
2
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1answer
57 views

Grignards and anhydrous ethanol

I remember using both 95% ethanol and absolute ethanol quite a few times. You'd need absolute ethanol for a reaction that would fail if water was present, such as a Grignard reaction. I can't ...
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69 views

Preparation of 6-bromo-1-hexanol

I am refluxing $\ce{HBr}$ with 1,6-hexanediol for 16 hours at $80\ ^\circ\mathrm{C}$ in toluene. How can I be sure that more than $90\,\%$ of the product is brominated only at one terminal? If the ...
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48 views

Ketone to alkene regiochemistry

What are the reagents for the following reactions: Typically, when thinking about ketone to alkene reactions, one thinks of the Wittig reaction. However, I don't see an appropriate form of that ...
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1answer
24 views

Can 4-pyridones be synthesised analogously to 2-pyridones?

I understand that 2-pyridone derivatives can be synthesized by oxidizing an N-methyl pyridinium salt with $\ce{[Fe(CN)6]^3-}$ under basic conditions. Can a similar method be used to produce ...
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1answer
51 views

Possible Synthesis of a Polymer

Following a question I have asked previously, what I intend to inquire this time is quite similar as well, except, with a polymer. So previously I asked whether such monomer PCDO is possible to ...
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1answer
83 views

Interlocked Cyclic Compounds

Being new to chemistry, there may ought to be some properties I couldn't understand fully. One of them being cyclic compounds. One particular question about this is, whether these cyclic compounds, ...
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65 views

Method of deriving some properties or possible method of synthesis of a specific monomer

This is kind of like two questions but since they're related I have put them together. Consider a monomer under a hopefully anatomically correct name 'Phenyl Carbolithia Divinylene Oxide ...
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1answer
102 views

Synthesis of bromobutane

What will be the cost efficient and high yielding method of synthesis for 1-bromobutane? I can react butanol with $\ce{HBr}$ but I am worried butanol is not present at the moment in lab. But I need ...
14
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1answer
108 views

Propose a chemical formula for the white solid that forms during the initial stages of the reaction of Sn with benzyl chloride

In my inorganic class, we carried out the synthesis of Chlorotribenzyltin, $\ce{SnCl(CH2C6H5)3}$. The synthesis begins with a reflux I'll describe below: In a hood, place 2.0 g (17 mmol) of 325 ...
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77 views

How to reduce an acyl group on a benzene without disturbing nitro group

Is it possible to reduce an acyl group to an alkane, but still keep a nitro group intact without its reduction to an amino group. A Clemmensen reduction would reduce the nitro group and it seems like ...
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224 views

Is it possible to oxidize ether to ester?

Is it possible to synthesize ester from an ether directly (only one step)? For example if I had an ether $\ce{(R-CH2-OR')}$ and oxidize it so it will be an ester $\ce{(R-CO-OR')}$.
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184 views

Nitration of pyrrole

Would 2,5-dinitropyrrole be a product of nitration of pyrrole with $\ce{H2SO4/HNO3}$ ? It seems from this paper that it is not formed using acetic anhydride/nitric acid. Is this just because of the ...
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144 views

Origin of alkenes from Wurtz Reaction

According to Wikipedia: Also, since the reaction involves free radical species, a side reaction occurs to produce an alkene. This side-reaction becomes more significant when the alkyl halides are ...
5
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1answer
79 views

Clemmensen reduction of 1,3 diketones

As part of a synthesis I was considering the following reaction: How selective is the Clemmensen reduction? I know that the Clemmensen reduction favours ketones adjacent to benzene rings but will ...
3
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1answer
51 views

Mechanism of enolether formation with ethyl orthoformate in estr-4-ene-3,17-dione (Djerassi's norethisterone synthesis)

The second step of Djerassi's synthesis of 19-nor-17α-ethynyltestosterone (norethindrone), involves the protection of the ketone in position 3 via enolether formation, as in the picture: What is ...
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100 views

Why might the O—H stretch in the IR of MY triphenylmethanol product be less intense than expected?

Why might the O—H stretch in the IR of MY triphenylmethanol product be less intense than expected when compared to the expected IR for triphenylmethanol? I'm interpreting the IR I took of my product, ...
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126 views

Synthesis of ethyl methyl ketone from 2-(4-hydroxyphenyl)ethyl methyl ketone

Is it possible to reduce raspberry ketone (4-(4-Hydroxyphenyl)butan-2-one) to ethyl methyl ketone? How would I do this in practice?
6
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85 views

Why can you not make a compound with a quaternary alpha carbon using malonic ester?

So my textbook tells me that using malonic ester to make a quaternary alpha carbon is impossible (I get that this might be hyperbole). However, it doesn't explain why and I don't understand why. My ...
7
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0answers
32 views

Will the sulfur-iodine cycle and Haber Method work at lower pressures and temperatures?

I have a year-long research project next year in my senior year of high school, in which we have to make some product or prototype to solve some issue. My interest was in the Liquid Fluoride ...
2
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1answer
49 views

Interaction between metalic nanoparticles and aggregation

I can't find any publication to deal with aggregation of colloidal metalic nanoparticles. What type of interaction(s) is/are there between aqeous metalic nanoparticles which give(s) rise to ...
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2answers
454 views

Conversion of Methane to Propane

Is it possible to chemically convert Methane into Propane? If so what is involved and is it economical? Thanks.
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38 views

How to synthesize Boron tri-fluoride using Boron Oxide

I am finding different equations for the synthesis. My lecture handout suggests a reaction with Sodium tetrafluroborate and Sulfuric acid. This is fine but I have to remember this for an exam and that ...
7
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2answers
182 views

Non-halogen intermediate between alkane and alcohol under basic conditions?

Using organic chemistry I have failed to find a method that doesn't involve halogens (gasseous especially). Please ignore the enzyme mono-oxygenase, which adds $\ce{O2}$ directly to alkanes to form ...
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164 views

Fluorescein synthesis

What is the mechanism of the fluorescein synthesis performed by von Baeyer?
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67 views

Synthesis of a bicyclo[2.2.2]octane from benzoic acid

I think that it is a Diels Alder reaction, but I don't recognize the start materials! First I make the tertiary alcohol from carboxylic acid with organo-lithium reagent; after I try to make a Diels ...
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1answer
128 views

Why, during aspirin synthesis in acidic conditions, anydride carbonyl oxygen is protonated rather than salicylic acid carbonyl oxygen ?

The common route for aspirin synthesis (described here) employs acetic anhydride and salicylic acid, in acidic conditions. The first step of such a reaction mechanism is the protonation of the ...
4
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1answer
59 views

Attack of amine on amide

I am confused with the last step of clozapine synthesis: How can the amine group attack the amide group to form the amidine in such acidic environment? Is the intermolecular reaction between an ...
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2answers
435 views

Oxidation of acetophenone to benzoic acid

According to the solutions manual, the oxidation of acetophenone to benzoic acid can be achieved through addition of chromic acid and application of heat. The solutions manual refers me to a section ...
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1answer
47 views

Permanent Balloon?

Is it possible to create a container for helium that it can't permeate through, like a permanent balloon? Or, if not, what kind of material would have the lowest permeability for that application? I ...
4
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1answer
213 views

Diels-Alder rate of reaction

Why is cyclopentadiene more reactive than 9-anthracenemethanol when acting as a diene? Both molecules are locked in an s-cis conformation, which is favourable. I'm thinking that it's due to the ...
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1answer
67 views

How do I synthesize 3-phenyl oxirane-2-carbaldehyde from chloroacetonitrile?

I start with the hydrolysis of the nitrile in carboxylic acid and esterification of this. After I use the Darzens' reaction (using benzaldehyde), then I reduce the ester function with DIBALH in ...
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52 views

Intramolecular hydrazide condensation

Say I have the compound $\ce{CH3CONHNH2}$. Is it possible, that when I add an acid, an intramolecular condensation reaction occurs, forming the cyclic compound: Furthermore, in general, the ...
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1answer
55 views

Grignard formation and vicinal dihalides

So let's say I have a symmetric 1,2-dihalide (the halides are identical) and I wanted to make a Grignard and I only add 1 eq. of magnesium metal ... Will I get 1 eq. of asymmetric Grignards (i.e. ...