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5
votes
2answers
61 views

What is the active ingredient in this “stimulant?”

It is an easily defensible argument that this is a medical question rather than a chemistry one, however, I feel that it leans ever so slightly towards chemistry, and so I posted it here. There is a ...
5
votes
1answer
1k views

How could alcohol be made into a powder?

In the news recently is 'Palcohol', powdered alcohol, http://www.palcohol.com/home.html that you add to water or existing liquids to make it alcohol. Presumably this would dissolve and break apart ...
3
votes
1answer
85 views

Determine compound acidity based on structure

In an exercise I have the following structures Moclobemide: Paracetamol: Hexobarbital: I know for example by heart that paracetamol is an acid. What is the best approach in determination of ...
0
votes
2answers
101 views

What is the importance of using a pka value instead of a pkb value when describing drug chemistry?

Why do we only consider the $pK_a$ value of a drug regardless of whether it is an acid or base? Why do we not use the $pK_b$ value?
0
votes
0answers
29 views

What happens to the structure of tetrayclines when they expire?

I need to explain (chemically) why expired tetracyclines should not be used, relating to the changes in tetracycline structure that occur. All I can find is that they cause nephrosis, etc, but not ...
4
votes
1answer
473 views

What does the “3,4” mean in 3,4-methylenedioxymethamphetamine (MDMA)?

I'm curious to know, what exactly does the 3,4 part of 3,4-methylenedioxymethamphetamine represent?
1
vote
3answers
275 views

Open Source tools to draw a set of 2d molecular graphs from sdf file

I have a sdf file for around 50 small-molecules for which I am doing structure-activity study. I would like to draw 2d graphs of all the molecules such that the image would fit into a single journal ...
1
vote
1answer
107 views

Prediction of surface atoms in molecule from its graph

If we are given a molecular graph i.e. al the atoms involved and their connectivity, how can we make reasonable prediction if the atom would lie in the surface or in the inner part. On way might be ...
1
vote
1answer
142 views

What is the effect of substituting oxygen with sulfur in drug molecules?

What sort of changes in the properties of organic or drug molecules can be anticipated if you substitute some or all of the oxygen atoms with sulphur atoms, and vice versa. My interest in this ...
0
votes
0answers
103 views

How would one go about Synthesising AM404 in the lab?

AM404 or N-(4-hydroxyphenyl)arachidonoylethanolamide is one of the active metabolites of paracetamol (acetaminophen) and is biosynthesized by means of the enzyme, fatty acid amide hydrolase, ...
1
vote
1answer
408 views

What does ingredients being “biologically active” mean?

From Wikipedia Cosmeceuticals refers to the combination of cosmetics and pharmaceuticals. Cosmeceuticals are cosmetic products with biologically active ingredients purporting to have medical ...
2
votes
1answer
642 views

Chemicals and killing bacteria question

Are there ways to compute what chemicals kill a give bacteria but not another given bacteria ? Does that help much to make medication ?
8
votes
1answer
217 views

Why does the sulfone ring in tazobactam open when the lactam is hydrolyzed?

One of the drugs I work with is a beta-lactam (4-membered ring with an amide bond) fused to a sulfone ring, tazobactam. It's relatively stable in water; the lactam is not significantly hydrolyzed ...
12
votes
1answer
364 views

What are known examples of drugs that racemize/stereoconvert in vivo, and how are they converted?

It is known that although only the (S)-enantiomer of the infamous sedative thalidomide possesses teratogenic properties, it is not very useful to administer the pure (R)-enantiomer since it is ...