Questions about chemicals and chemical processes that affect and influence medicine.

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Regarding the mechanism for biological activity of tyramine, amphetamine and ephedrine

Graham Patrick explains the mechanism for the activity of tyramine, amphetamine and ephedrine in his book Introduction to Medicinal Chemistry as follows: Some amines such as tyramine , ...
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Combining amphetamine and MAOIs

Could combining amphetamine and a (possibly selective) MAOI (MonoAmine Oxidase Inhibitor) increase the amphetamines potency without serious toxic side effects? If so by what factor, and would this be ...
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1answer
77 views

Are the tars in cannabis considerably more dangerous than those in tobacco?

The claim that "the tars in cannabis are considerably more dangerous than those in tobacco" is made in Patricks An Introduction to Medicinal Chemistry (4th edition, p. 169). It's just a simple one ...
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14 views

Need a stable qualitative test for acetoacetic acid

I am looking at using urine ketone test strips (Ketostix) for a project. I have some technical limitations: must be able to be flooded with urine for 2 hours without creating a false negative (some ...
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1answer
39 views

Skin adhesive that can be used daily without damaging skin

What is the branch of chemistry that deals with skin adhesives? Is there an adhesive that is not water soluble that is safe to use every day?
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34 views

Urine dipstick reagent for ketones

Is there a urine dipstick reagent for ketones that will last several hours without becoming falsely negative? The ketostix brand of urine dipstick for ketones uses sodium nitroprusside. My ...
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1answer
37 views

How are hormone levels measured?

I have been searching google and didn't found any links that describes how this process is performed - I mean the chemical procedure, not the process of taking the blood from the vein.
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1answer
104 views

How important are those fields of chemistry in biotechnology and medicinal chemistry

At my university there is some fields of chemistry that i don't know if i should focus on them... How important are in biotechnology and medicinal chemistry those fields of chemistry? : Quantum ...
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18 views

PAPS , is it a carrier or not

In sulfate conjugation , is it considered as a carrier or help to make sulfonation if I got a question and I have to choose ( enzyme helps to make the reaction or is a carrier to transfer the sulfate ...
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1answer
77 views

Why is acetylsalicylic acid still more acid than benzoic acid?

In this question, it is explained why salicylic acid is a stronger acid than benzoic acid. So, why acetylsalicylic acid (aspirin), whose conjugate base cannot hydrogen bond since there is no hydrogen, ...
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115 views

Is there a way to turn alcohol into a solid gel?

I'm wondering if there is a way to turn alcohol or another bacteria killing substance into a solid gel form, sort of like the gel you can use to clean a keyboard. Source: Aliexpress.com Computer ...
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3answers
710 views

Can we prolong life? [closed]

This is rather a bunch of questions that I decided to post on Chemistry StackExchange since I thought the chemists would have the most knowledge about the chemical processes of life. So recently I ...
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1answer
81 views

Why does the US not manufacture sodium thiopental themselves?

A shortage of a given chemical (sodium thiopendal) has prompted Utah to allow firing squads for executions. This shortage is due to mostly European chemical factories refusing to export the drug to ...
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1answer
39 views

Looking for a compound [closed]

TL;DR; I need a compound that is harmeless to the human body, odorless, tasteless, causes some kind of visible reaction (urine coloration perhaps) AND can be bought without medical recomendation. LONG ...
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3answers
157 views

Is it possible to make a drug that liquefies heart plaque to treat heart disease?

Is it possible to make a drug that liquefies heart plaque to treat heart disease without damaging other parts of the body? If so, would the liquefied plaque be eliminated as regular fluid is through ...
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1answer
614 views

Are there any magnetic particles that are safe to inhale?

In medicine, there is an (old?) experiment where a subject is asked to inhale radioactive Xenon gas, and radiation counters are placed at different positions near the lungs. Using this experiment, it ...
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1answer
45 views

Hydrolysing large molecules to reveal amino acids

Consider Oxytocin: I am asked to hydrolyse Oxytocin and reveal 5 amino acids which are the result of this hydrolysis. I must admit I have no idea where to begin. I know that generally amino acids ...
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2answers
269 views

Chirality on Propranolol

I'm a bit confused when asked to specify the chiral carbons on this sketch of Propranolol as I'm not sure how the $\ce{H3C}$ and $\ce{CH3}$ play in if they are reversed in the name like that...Does ...
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1answer
438 views

Negative ions and health: pseudo science or something more?

Over the last year or so I've heard from friends, who subscribe to holistic medicine, talk about negative ions, saying that they are good for your mental/physical health. Being the only one among them ...
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1answer
400 views

Why do many pharmaceuticals contain fluorine?

What exactly does fluorination of some compound do in a biological sense? I read the following things about what fluorine does for drugs: Fluorine withdraws electron density and can make an acid ...
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1answer
978 views

Interpreting a Formula Tattoo (Bipolar?)

Found This Online. Something to do with bipolar disorder?
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1answer
117 views

How to Experimentally Quantify the Response of a Receptor to a Ligand?

In medicinal chemistry, there are multiple reasons why one would want to experimentally determine the effect of a particular molecule on a receptor e.g. measuring how 'strongly' that molecule brings ...
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2answers
282 views

Why does blood get further oxidized than Iron oxide?

Oxygenated blood is bright red and deoxygenated blood is dark red or brown. If you take oxygenated blood and leave it in the air it will turn dark red, then brown, then finally a bluish green from ...
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1answer
71 views

Are salt substitutes good alternatives to sodium chloride?

I bought a low salt Ketchup from Heinz and it says it uses ‘ALSOSALT’ substitute (potassium chloride). It says it does have 5 mg of sodium. Is potassium chloride (with possible additives) a good ...
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164 views

What is the active ingredient in this “stimulant?”

It is an easily defensible argument that this is a medical question rather than a chemistry one, however, I feel that it leans ever so slightly towards chemistry, and so I posted it here. There is a ...
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1answer
2k views

How could alcohol be made into a powder?

In the news recently is 'Palcohol', powdered alcohol, http://www.palcohol.com/home.html that you add to water or existing liquids to make it alcohol. Presumably this would dissolve and break apart ...
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1answer
290 views

Determine compound acidity based on structure

In an exercise I have the following structures Moclobemide: Paracetamol: Hexobarbital: I know for example by heart that paracetamol is an acid. What is the best approach in determination of ...
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2answers
224 views

What is the importance of using a pKa value instead of a pKb value when describing drug chemistry?

Why do we only consider the $\mathrm{p}K_\text{a}$ value of a drug regardless of whether it is an acid or base? Why do we not use the $\mathrm{p}K_\text{b}$ value?
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56 views

What happens to the structure of tetrayclines when they expire?

I need to explain (chemically) why expired tetracyclines should not be used, relating to the changes in tetracycline structure that occur. All I can find is that they cause nephrosis, etc, but not ...
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1answer
1k views

What does the “3,4” mean in 3,4-methylenedioxymethamphetamine (MDMA)?

I'm curious to know, what exactly does the 3,4 part of 3,4-methylenedioxymethamphetamine represent?
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3answers
578 views

Open Source tools to draw a set of 2d molecular graphs from sdf file

I have a sdf file for around 50 small-molecules for which I am doing structure-activity study. I would like to draw 2d graphs of all the molecules such that the image would fit into a single journal ...
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1answer
195 views

Prediction of surface atoms in molecule from its graph

If we are given a molecular graph i.e. al the atoms involved and their connectivity, how can we make reasonable prediction if the atom would lie in the surface or in the inner part. On way might be ...
3
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1answer
443 views

What is the effect of substituting oxygen with sulfur in drug molecules?

What sort of changes in the properties of organic or drug molecules can be anticipated if you substitute some or all of the oxygen atoms with sulphur atoms, and vice versa. My interest in this ...
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1answer
1k views

What does ingredients being “biologically active” mean?

From Wikipedia Cosmeceuticals refers to the combination of cosmetics and pharmaceuticals. Cosmeceuticals are cosmetic products with biologically active ingredients purporting to have medical ...
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930 views

Are there ways to predict which chemicals will kill certain bacteria?

Are there ways to compute what chemicals kill a give bacteria but not another given bacteria ? Does that help much to make medication ?
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1answer
399 views

Why does the sulfone ring in tazobactam open when the lactam is hydrolyzed?

One of the drugs I work with is a beta-lactam (4-membered ring with an amide bond) fused to a sulfone ring, tazobactam. It's relatively stable in water; the lactam is not significantly hydrolyzed ...
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1answer
668 views

What are known examples of drugs that racemize/stereoconvert in vivo, and how are they converted?

It is known that although only the (S)-enantiomer of the infamous sedative thalidomide possesses teratogenic properties, it is not very useful to administer the pure (R)-enantiomer since it is ...