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5
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1answer
342 views

Are there any magnetic particles that are safe to inhale?

In medicine, there is an (old?) experiment where a subject is asked to inhale radioactive Xenon gas, and radiation counters are placed at different positions near the lungs. Using this experiment, it ...
1
vote
1answer
42 views

Hydrolysing large molecules to reveal amino acids

Consider Oxytocin: I am asked to hydrolyse Oxytocin and reveal 5 amino acids which are the result of this hydrolysis. I must admit I have no idea where to begin. I know that generally amino acids ...
2
votes
2answers
170 views

Chirality on Propranolol

I'm a bit confused when asked to specify the chiral carbons on this sketch of Propranolol as I'm not sure how the $\ce{H3C}$ and $\ce{CH3}$ play in if they are reversed in the name like that...Does ...
1
vote
1answer
20 views

Chemistry books with a clinical perspective (not pharmacology)

I am looking for a book on chemistry (introductory if possible) with a clinical perspective. Something that would focus on the concepts, methods, etc. that are particularly important for medicine. It ...
8
votes
1answer
127 views

Negative ions and health: pseudo science or something more?

Over the last year or so I've heard from friends, who subscribe to holistic medicine, talk about negative ions, saying that they are good for your mental/physical health. Being the only one among them ...
6
votes
1answer
340 views

Why do many pharmaceuticals contain fluorine?

What exactly does fluorination of some compound do in a biological sense? I read the following things about what fluorine does for drugs: Fluorine withdraws electron density and can make an acid ...
1
vote
1answer
538 views

Interpreting a Formula Tattoo (Bipolar?)

Found This Online. Something to do with bipolar disorder?
1
vote
1answer
96 views

How to Experimentally Quantify the Response of a Receptor to a Ligand?

In medicinal chemistry, there are multiple reasons why one would want to experimentally determine the effect of a particular molecule on a receptor e.g. measuring how 'strongly' that molecule brings ...
2
votes
2answers
141 views

Why does blood get further oxidized than Iron oxide?

Oxygenated blood is bright red and deoxygenated blood is dark red or brown. If you take oxygenated blood and leave it in the air it will turn dark red, then brown, then finally a bluish green from ...
1
vote
1answer
29 views

Are salt substitutes good alternatives to sodium chloride?

I bought a low salt Ketchup from Heinz and it says it uses 'ALSOSALT' substitute ( potassium chloride). It says it does have 5mg. of sodium. Is potassium chloride (with possible additives) a good ...
5
votes
2answers
108 views

What is the active ingredient in this “stimulant?”

It is an easily defensible argument that this is a medical question rather than a chemistry one, however, I feel that it leans ever so slightly towards chemistry, and so I posted it here. There is a ...
7
votes
1answer
2k views

How could alcohol be made into a powder?

In the news recently is 'Palcohol', powdered alcohol, http://www.palcohol.com/home.html that you add to water or existing liquids to make it alcohol. Presumably this would dissolve and break apart ...
3
votes
1answer
191 views

Determine compound acidity based on structure

In an exercise I have the following structures Moclobemide: Paracetamol: Hexobarbital: I know for example by heart that paracetamol is an acid. What is the best approach in determination of ...
0
votes
2answers
157 views

What is the importance of using a pka value instead of a pkb value when describing drug chemistry?

Why do we only consider the $pK_a$ value of a drug regardless of whether it is an acid or base? Why do we not use the $pK_b$ value?
0
votes
0answers
47 views

What happens to the structure of tetrayclines when they expire?

I need to explain (chemically) why expired tetracyclines should not be used, relating to the changes in tetracycline structure that occur. All I can find is that they cause nephrosis, etc, but not ...
6
votes
1answer
802 views

What does the “3,4” mean in 3,4-methylenedioxymethamphetamine (MDMA)?

I'm curious to know, what exactly does the 3,4 part of 3,4-methylenedioxymethamphetamine represent?
1
vote
3answers
415 views

Open Source tools to draw a set of 2d molecular graphs from sdf file

I have a sdf file for around 50 small-molecules for which I am doing structure-activity study. I would like to draw 2d graphs of all the molecules such that the image would fit into a single journal ...
3
votes
1answer
174 views

Prediction of surface atoms in molecule from its graph

If we are given a molecular graph i.e. al the atoms involved and their connectivity, how can we make reasonable prediction if the atom would lie in the surface or in the inner part. On way might be ...
3
votes
1answer
309 views

What is the effect of substituting oxygen with sulfur in drug molecules?

What sort of changes in the properties of organic or drug molecules can be anticipated if you substitute some or all of the oxygen atoms with sulphur atoms, and vice versa. My interest in this ...
1
vote
1answer
812 views

What does ingredients being “biologically active” mean?

From Wikipedia Cosmeceuticals refers to the combination of cosmetics and pharmaceuticals. Cosmeceuticals are cosmetic products with biologically active ingredients purporting to have medical ...
2
votes
1answer
804 views

Are there ways to predict which chemicals will kill certain bacteria?

Are there ways to compute what chemicals kill a give bacteria but not another given bacteria ? Does that help much to make medication ?
9
votes
1answer
310 views

Why does the sulfone ring in tazobactam open when the lactam is hydrolyzed?

One of the drugs I work with is a beta-lactam (4-membered ring with an amide bond) fused to a sulfone ring, tazobactam. It's relatively stable in water; the lactam is not significantly hydrolyzed ...
13
votes
1answer
554 views

What are known examples of drugs that racemize/stereoconvert in vivo, and how are they converted?

It is known that although only the (S)-enantiomer of the infamous sedative thalidomide possesses teratogenic properties, it is not very useful to administer the pure (R)-enantiomer since it is ...