The scientific study of chemical processes in living organisms, including, but not limited to, living matter.

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Water+Light+Temperature+Time = Life?

If we would put together to ~one place: Water enough Light optimal Temperature enough Time etc. Then atoms will be formed and according to Organic Chemistry, we would get "Life"? Is this an ...
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79 views

How can a protein folding transition state have zero lifetime?

I'm doing a module on my Biochemistry course looking at protein folding, and in a discussion of [folding] transition states I was a little confused at the thought of a zero-lifetime transition state - ...
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22 views

How to analytically quantify a chemical's potential to intercalate DNA?

This shows that polyphenols (like quercetin) have the potential to intercalate DNA, but at potency 100x less than that of ethidium bromide. How does one analytically measure/quantify "100x weaker"? ...
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23 views

How does sulbutiamine work in the same way as thiamine, even if it doesn't have a thiazole ring?

So sulbutiamine is said to be a thiamine substitute. Yet - it doesn't contain the thiazole ring that's so important for many of thiamine's functions.
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20 views

What are the metabolites and method of action of Contrave, Belviq or Phentermine?

The SE staff spurred me into wondering about diet pills. What are the metabolites and method of action of Contrave, Belviq or Phentermine?
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13 views

How does Temperature influences the rate of protein turnover?

A very similar question I asked can be found here. It seems that this other question as I formulated it has a hard time attracting answer, so I'm giving another try with a slightly different question. ...
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30 views

Algorithm that calculates damage from adrafinil?

is there such a thing that calculated damage of adrafinil based on dosage? lets say i take a dosage of 100mg/ day for 100 days, what would the affect be? how much % of my liver will be damaged? Do ...
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28 views

ATP break down and energy release?

I have a very basic question. Energy is absorbed to break bonds. Bond-breaking is an endothermic process. Energy is released when new bonds form. Bond-making is an exothermic process. But ATP breaks ...
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23 views

How do I figure out where velocity declines?

I am stumped on one question on my biochem practice problems. We went over all of them today but my whole group was unable to figure out how to properly set up the equations to calculate the change in ...
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16 views

What trends affect hydrophobicity in amino acids?

I was wondering if the length of the carbon backbone affects hydrophobicity of amino acids (i.e. longer carbon backbone of side group = less polar = more hydrophobic).
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16 views

Procedure of Hydrate Lab

How do you find the formula of a hydrate when given an impure substance? Is there any procedure to find this out in a laboratory setting?
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24 views

How does life choose it's nominal temperature preferences?

If all life relies on water, and water freezes at 32F and boils at 212F. Then why isn't the nominal temperature for life 122F? 122F will literally kill some animals, including us. Do our ...
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Delta G values for Pyruvate--> Alanine vs. Oxaloacetate -> Aspartate ->Asparagine

What are the delta G values for the mammalian (human) biosynthesis of alanine from pyruvate, and for the conversion of oxaloacetate to asparagine? (assuming no particular cellular restriction or other ...
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168 views

Influence of Temperature on Biochemical Reactions

Short question How (quantitatively speaking) does temperature influences rate of decay of proteins? I am looking for some general number/function, the influence of temperature on an average protein. ...
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19 views

Book recommendations for protein structure refinement

I’m an undergraduate Chemistry student and I’m currently writing my dissertation about semi-empirical methods, particularly PM7, applied to protein structure refinement from X-ray structure. Could you ...
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36 views

What is the formula for migration rate of DNA in agarose gel electrophoresis?

Let's consider a typical agarose gel electrophoresis experiment. An appropriate quantity (not so much that it is overloaded, but not so little that it cannot be visualized) of linear DNA pieces with ...
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1answer
24 views

Predicting 260/280 of DNA or RNA from sequence?

I asked this in biology, but I think they don't want to deal with the chemistry behind UV-Vis. My question has to do with the Poly A tails on mRNA. I've been doing in vitro transcription and tailing ...
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3answers
66 views

Which software is suitable to calculate the root mean square deviation between two protein structures?

I need to compute the root mean square deviation (RMSD) between two protein structures: the X-ray determined protein structure and the MOPAC optimized structure. Which software do you suggest?
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63 views

What happens if you autoclave HEPES?

Many molecular biology protocols advice against sterilizing HEPES (4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid) solutions by autoclave. Supposedly, HEPES is heat labile, and the high ...
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10 views

Enzyme Assay - pectinase

I am working on Enzyme Assay.I assayed the enzyme in different buffers from $pH\ 1-12.5$ However,the enzyme has good activities starting from $pH\ 1-10.5$ Is that possible to have enzyme activity in ...
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45 views

Using Hydrates as a skin moisturizer

I was just in my AP Chemistry class earlier today learning about hydrates and their properties. It occurred to me that a compound with so much water could aid in moisturizing the skin. Is this a valid ...
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34 views

What is the reason for particular reaction rates for oxidation, combustion, and metabolic reactions?

We are currently working with reaction rates in Chemistry. I need some help with a question for the upcoming test. "Give examples of phenomenons or products and explain why they have a certain ...
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1answer
72 views

What element or compound could be used to create a more base ocean?

The ocean is becoming acidic. This is not a natural evolutionary change but happens through human negative effect on the environment. What element or compound could be used to create a more base ...
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521 views

Biological Consequences of Asteroid Mining—Death by Isotope?

It's been documented that NASA hope to capture an asteroid in 2025, and have subsequent aims to mine that asteroid. If if this is successful, we would expect other asteroids to be mined in the future. ...
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36 views

How can I measure carcinogenic risks of an M-ENDO-Agar LES substrate after heat destruction?

I'm about to conduct a study of possible toxic traces from the substance M-ENDO-Agar LES in substrate after destruction with heat (I think it is 160℃) for 180 minutes. The substance is carcinogenic. ...
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25 views

Why are non-polar hydrogens neglected in protein-drug binding studies?

Why are (Non-polar) Hydrogen generally neglected in a protein-ligand (or drug) binding energy calculation? They do have charge and mass. Doesn't that affect the free energy calculation?
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68 views

Mercury brain half-life

If have read conflicting reports on the half-life of mercury in the brain. I would like to hear some estimates from this community. I am also wondering how long chelation therapy would take to remove ...
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25 views

Mercury binding agents which cross the blood brain barrier

The two substances I have come across are cilantro and lipoic acid. How effective would either of them be? Are there any other agents known which produce the desired results?
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18 views

removing mercury from the brain

I have conducted many searches on this subject with regards to agents which cross the blood brain barrier. I have read about lipoic acid. Is anybody on here aware of any studies or findings which show ...
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35 views

Mercury vapor release from amalgam fillings

What would cause vapour release from elemental mercury? Would it be pressure, friction... could one stop the vapour release through cooling the mercury?
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64 views

About all the pop drinks being sold

Regarding chemical synergies I read if someone ingests various product with sodium benzoate (forgive spelling) like the MANY soft drinks that exist ; AND if one has had some quantity of vitamin C ...
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306 views

What are these crystals on my champagne cork?

I opened up a bottle of champagne that was left in a wine cooler for approx. 8 years. To my astonishment there were small crystals at the underside of the cork. The crystals are colorless, odorless ...
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29 views

What makes sulfur-containing compounds such good antioxidants?

Many sulfur-containing compounds (like glutathione and cysteine groups) have high antioxidant activity. Why?
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44 views

Psychoactive ingredients in this soap?

Could any ingredients from this product be psychoactive in some people, if the are sensitive to them? https://www.lush.co.uk/products/honey-i-washed-kids I have found the product to be relaxing as ...
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32 views

Bohr Effect - related to H+ only?

Would I be correct in saying that the Bohr effect is ONLY related to the concentration of [H+] in the tissues. Obviously the concentration of carbon-dioxide can contribute to this concentration by ...
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57 views

Why is the deprotonated form of dopamine more reactive than the protonated/neutral form of dopamine?

See this (from the Wikipedia article on dopamine): Dopamine, like most amines, is an organic base. At neutral or acidic pH levels it is generally protonated. The protonated form is highly ...
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63 views

Does vinegar neutralize the strongly basic compounds in cement?

I have heard that washing one's hands with vinegar is effective in neutralizing the strong bases in cement and is more effective than water. I want to know how cement burns and what bases are ...
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17 views

What happen when there is no salt bridge in microbial fuel cell?

I wonder if there is no salt bridge on microbial fuel cell, Are there have the same amount of current or none?
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1answer
54 views

Greater entropy: an atom or macromolecule?

A question that appeared on my last chemistry exam was : Which of the following has greater entropy A) An atom B) A macromolecule The question doesn't specify anything else(i.e. type/size ...
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22 views

Quaternary ammonium anti-microbials

Also good against fungi, amoeba, and enveloped viruses,[7] quats are believed to act by disrupting the cell membrane. Quaternary ammonium cleaners have long-alkyl substituent chains. Why is this ...
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74 views

What is the mechanism of monofunctional glycosylase catalysis? [closed]

I am learning about base excision repair mechanisms. I understand the main idea how glycosylases are working, but I am trying to understand this in much more detail. I found a paper where they have ...
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1answer
51 views

Is Chemical Engineering a good pathway to Biomedical Engineering for graduate school? [closed]

I have been thinking about my future goals and I have recently decided to go for Biomedical Engineering. sites recommend to start in Chemical Engineering because its a good pathway for biomedical ...
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47 views

What is the difference between protein domains, motifs, and supersecondary structures?

I was just wondering if there is any difference between supersecondary structure and motifs. As well, is a protein domain an independently folded region of a protein that has a particular function ...
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71 views

What is the active ingredient in this “stimulant?”

It is an easily defensible argument that this is a medical question rather than a chemistry one, however, I feel that it leans ever so slightly towards chemistry, and so I posted it here. There is a ...
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1answer
48 views

Human Body and RNA/DNA

After research I found that enzymes are responsible for metabolism, specifically catabolism and anabolism. This in turn creates the necessary chemicals in your body. The only question left is: what ...
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1answer
102 views

Units for dissociation constant and relationship to Gibbs Free Energy

How does one "convert" between an equilibrium constant calculated from the Gibbs free energy for a dissociation reaction and experimentally determined dissociation constants? $$ \Delta ...
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1answer
44 views

How is chlorophyll made in plants?

I've been studying photosynthesis and something made me think about how chlorophyll itself is made in plants.How exactly is it formed ?
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360 views

Basic chemistry of the Shinoda test for flavonoids?

In this test, four pieces of magnesium fillings (ribbon) are added to the ethanolic extract followed by a few drops of concentrated hydrochloric acid. A reddish colour indicates the presence of ...
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Simulating enzymatic change rates of Carbonic anhydrase

I'm trying to simulate effects of carbonic anhydrase on cellular pH as caused by changes in bicarbonate. I assume a bicarbonate homeostatic mechanisms which replenishes intracellular conenctrations ...
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1answer
45 views

What does the adenosine do in ATP?

This is an extremely basic question about biochemistry from someone who doesn't know much about organic chemistry. I'm aware of how organisms store energy ATP and release it by dephosphorylating it ...