Chemistry Stack Exchange is a question and answer site for scientists, academics, teachers and students. Join them; it only takes a minute:

Sign up
Here's how it works:
  1. Anybody can ask a question
  2. Anybody can answer
  3. The best answers are voted up and rise to the top

The chemical structure of the compounds in question are:


Figure 1: Hyperforin

enter image description here

Figure 2: Tetrahydrohyperforin

enter image description here

Figure 3: Octahydrohyperforin

Would heating hyperforin in the presence of water manage to saturate the required bonds and thus allow one to synthesise these compounds?

share|improve this question
up vote 3 down vote accepted

That route won't work.

You need a hard base reduction that does not attack the enone, or you need to protect the enone to make Tetrahydrohyperforin.

Catalytic hydrogenation that is selective against carbonyl reduction is necessary to make Octahydrohyperforin.

share|improve this answer

Your Answer


By posting your answer, you agree to the privacy policy and terms of service.

Not the answer you're looking for? Browse other questions tagged or ask your own question.